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논문 기본 정보

자료유형
학술대회자료
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한국유체기계학회 한국유체기계학회 학술대회 논문집 유체기계공업학회 제4회 한국유체공학학술대회 논문집 (제2권)
발행연도
2006.8
수록면
1,035 - 1,038 (4page)

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초록· 키워드

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Erythrocyte aggregation is a physiological assemblage of red blood cells into neat stack like structure as though cells were placed one over / beside another like coins. Such stack of RBC interconnects to form three-dimensional networks often referred to as rouleaux in presence of plasma proteins aided by low flow. These neatly looking erythrocyte aggregates can turn into ugly, haphazard clump of cells under pathological conditions. Aggregational pathology can thus hamper blood flow, increase flow resistance and some times cause occlusion of blood vessels afflicting the microcirculatory rheology. This paper presents recent research report evidencing aggregational pathology in disease condition obtained through an in-vitro microhemofludic visualization system (μHVS). In a study conducted on normal and malaria infected subjects, erythrocyte aggregation showed irregular shapes and compactness aggregates when compared to the normal ones. Specific erythrocyte aggregates were rolling about themselves showing little or no deformation. While the aggregates of normal samples showed porous rouleaux network changing shape and orientation. Such deformation of rouleaux network was not seen among the clumped cells of parasitized samples. Erythrocytes were found adhering to each other and formed clumps tending toward agglutination. These results showed the extent to which microrheologic dysfunction could occur in severe cases of a specific disease.

목차

Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion and Conclusions
References

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UCI(KEPA) : I410-ECN-0101-2010-554-002112216