지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.3
- 수록면
- 48 - 54 (7page)
이용수
초록· 키워드
오류제보하기
Epileptifrom discharges were induced in the telencephalon of the adult zebrafish via perfusion with pentylenetetrazole (PTZ), bicuculline methiodide, kainic acid-treated artificial cerebrospinal fluid (aCSF), and Mg<SUP>2+</SUP>-free aCSF. Ginseng total saponin [GTS (50 ㎍/ml)] was shown to attenuate the occurrence rate of epilpetiform discharges by 50-75%, compared to the control. Ginsenoside Rg₁ (130 ㎛) reduced the epileptiform discharges in the isolated telenephalon and delayed the occurrence of behavioral seizures observed from the adult zebrafish placed in the PTZ (10 mM)-containing aquarium water. However, Re was not effective in the suppression of epileptiform discharges and behavioral seizures. These results indicate that Rg1 may be useful in the control of epileptiform discharges and effective in controlling behavioral seizures, and that the zebrafish can be used as a model animal for the testing of potential anticonvulsant drugs.
목차
Abstract
INTRODUCTION
MATERIALS AND METHOD
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (13)
참고문헌 신청
1. [학술지(정기간행물)] - Kim, Y. J. / 2004 / Identification and functional evidence of GABAergic neurons in parts of the brain of adult zebrafish (Danio rerio) / Neurosci. Lett. 355 : 29 ~ 32
2. [학술지(정기간행물)] - Nam, R. H. / 2004 / NMDA receptor-dependent long-term potentiation in the telencephalon of the zebrafish / Neurosci. Lett. 370 : 248 ~ 251
3. [학술지(정기간행물)] - Baraban, S. C. / 2007 / Emerging epilepsy models : insights from mice, flies, worms and Fish / Curr. Opin. Neurol. 20 : 165 ~ 168
4. [학술지(정기간행물)] - Berghmans, S. / 2007 / Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants / Epilepsy Res. 75 : 18 ~ 28
5. [학술지(정기간행물)] - Winter, M. J. / 2008 / Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs / J. Pharmacol. Toxicol. Methods. 57 : 176 ~ 187
2. [학술지(정기간행물)] - Nam, R. H. / 2004 / NMDA receptor-dependent long-term potentiation in the telencephalon of the zebrafish / Neurosci. Lett. 370 : 248 ~ 251
3. [학술지(정기간행물)] - Baraban, S. C. / 2007 / Emerging epilepsy models : insights from mice, flies, worms and Fish / Curr. Opin. Neurol. 20 : 165 ~ 168
4. [학술지(정기간행물)] - Berghmans, S. / 2007 / Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants / Epilepsy Res. 75 : 18 ~ 28
5. [학술지(정기간행물)] - Winter, M. J. / 2008 / Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs / J. Pharmacol. Toxicol. Methods. 57 : 176 ~ 187
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