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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Geldanamycin is a benzoquinone ansamycin antibiotic that binds to cytosol HSP90 (Heat Shock Protein 90) and changes its biological function. HSP90 is involved in the intracellular important roles for the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis. To identify genes expressed during geldanamycin treatment against neurons of rats (PC12 cells), DNA microarray method was used. We have isolated 2 gene groups (upor down-regulated genes) which are geldanamycin differentially expressed in neurons. Granzyme B is the gene most significantly increased among 204 up-regulated genes (more than 2 fold over-expression) and Chemokine (C-C motif) ligand 20 is the gene most dramatically decreased among 491 down-regulated genes (more than 2 fold down-expression). The gene increased expression of Cxcl10, Cyp11a1, Gadd45a, Gja1, Gpx2, Ifna4, Inpp5e, Sox4, and Sti ... 전체 초록 보기
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참고문헌 (8)
참고문헌 신청
1. [학술지(정기간행물)] - Dharmadi Y / 2004 / DNA microarrays: experimental issues, data analysis, and application to bacterial systems / Biotechnol Prog 20 : 1309 ~ 1324
2. [학술지(정기간행물)] - Drysdale MJ / 2006 / Schoepfer J. Targeting Hsp90 for the treatment of cancer / Curr Opin Drug Discov Deve 9 : 483 ~ 495
3. [학술지(정기간행물)] - Hu Z / 2004 / Isolation and characterization of novel geldanamycin analogues / J Antibiot 57 : 421 ~ 428
4. [학술지(정기간행물)] - López-Maderuelo MD / 2001 / Opposite effects of the Hsp90 inhibitor Geldanamycin: induction of apoptosis in PC12, and differentiation in N2A cells / FEBS Lett 490 : 23 ~ 27
5. [학술지(정기간행물)] - Powers MV / 2006 / Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors Endocr Relat Cancer / Suppl 1 : S125 ~ 135
2. [학술지(정기간행물)] - Drysdale MJ / 2006 / Schoepfer J. Targeting Hsp90 for the treatment of cancer / Curr Opin Drug Discov Deve 9 : 483 ~ 495
3. [학술지(정기간행물)] - Hu Z / 2004 / Isolation and characterization of novel geldanamycin analogues / J Antibiot 57 : 421 ~ 428
4. [학술지(정기간행물)] - López-Maderuelo MD / 2001 / Opposite effects of the Hsp90 inhibitor Geldanamycin: induction of apoptosis in PC12, and differentiation in N2A cells / FEBS Lett 490 : 23 ~ 27
5. [학술지(정기간행물)] - Powers MV / 2006 / Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors Endocr Relat Cancer / Suppl 1 : S125 ~ 135
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