지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2008.11
- 수록면
- 25 - 30 (6page)
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The circling (cir/cir) mouse is one of the murine models for human non-syndromicdeafness DFNB6. The mice have abnormal circling behavior, suggesting a balanced disorder and profound deafness. The causative gene was trans membrane inner ear (tmie) gene of which the mutation is a 40-kilobase genomic deletion including tmie gene itself. In this study, tmie-over expression trasngenic mice were established. Individuals with germline transmission have been mated with circling homozygous mutantmice (cir/cir) in order to produce the transgenic mutant mice (cir/cir-tg) as agenetherapy. After the genotyping, phenotypic analyses were performed so that the insertion of the new gene might compensate for the diseases such as hearingloss, circling behavior, or swimming inability. Some individuals exhibited complete recovery in their behavior and hearing but the others did not show any amelioration in behavioror hearing. Individual mice had very different levels of tmie transgene expression in the cochlea. These results clearly indicate that tmie protein plays an important role when the appropriate expression level of tmie was expressed in the innerear. The protein levels were variable in each individual and these are thought to induce the differences in disease amelioration levels.
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Ectopic expression of tmie transgene induces various recovery levels of behavior and hearing ability in the circling mouse
한국실험동물학회 학술발표대회 논문집
2008 .11
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Tmie rescued lesion of circling mouse
한국실험동물학회 학술발표대회 논문집
2011 .02
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Expression of deafness protein Tmie in postnatal developmental stages of C57BL/6J mice
Laboratory Animal Research
2012 .06
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Subcellular localization of the transmembrane inner ear (Tmie) protein in a stable Tmie-expressing cell line
Laboratory Animal Research
2011 .12
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The Introduction of Tmie can Recover the Hearing and Balance Inability of the Circling Mice
한국실험동물학회 학술발표대회 논문집
2009 .08
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The Introduction of tmie can recover the Hearing and Balance Inability of the Circling Mice
한국실험동물학회 학술발표대회 논문집
2009 .04
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The Recovery Levels in the Circling Mouse with Transmembrane Inner Ear (tmie) Gene Are Dependent on the amount of Expression in the Cochlea
한국실험동물학회 학술발표대회 논문집
2010 .02
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The Different Recovery Levels in the Circling Mouse with Transmembrane Inner Ear (tmie) Gene are Dependent on the Pattern of Expression in the Cochlea
한국실험동물학회 학술발표대회 논문집
2010 .08
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Tmie is Necessary Protein for Mechanotransduction of Hair Cells
한국실험동물학회 학술발표대회 논문집
2014 .02
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The Different Rescue Levels in the Circling Mouse with Transmembrane Inner Ear (Tmie) Gene are Dependent on the Expression Patterns of Transgene in the Cochlea
한국실험동물학회 학술발표대회 논문집
2009 .08
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The different rescue levels in the circling mouse with Transmembrane inner ear (tmie) gene are dependent on the expression patterns of transgene in the cochlea
한국실험동물학회 학술발표대회 논문집
2008 .11
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The different rescue levels in the circling mouse with Transmembrane inner ear (tmie) gene are dependent on the expression patterns of transgene in the cochlea
한국실험동물학회 학술발표대회 논문집
2008 .05
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Introduction of transmembrane inner ear (tmie) gene can recover the hearing impairment and abnormal behavior in the circling mouse
한국실험동물학회 학술발표대회 논문집
2008 .11
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Introduction of transmembrane inner ear (tmie) gene can recover the hearing impairment and abnormal behavior in the circling mouse
한국실험동물학회 학술발표대회 논문집
2008 .05
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Production and Characterization of Polyclonal Antibody to Transmembrane Inner Ear Protein
Laboratory Animal Research
2009 .06
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Circling mouse has a 40Kb genomic deletion which includes transmembrane inner ear protein (tmie) gene
한국실험동물학회 학술발표대회 논문집
2008 .05
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The entire structures of tmie and RN49018 are deleted in the circling mice
한국실험동물학회 학술발표대회 논문집
2010 .02
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The entire structures of tmie and RN49018 are deleted in the circling mice
한국실험동물학회 학술발표대회 논문집
2010 .08
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Subcellular localization of transmembrane inner ear (Tmie) protein in a stable Tmie-expressing cell line
한국실험동물학회 학술발표대회 논문집
2012 .02
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Circling 행동과 청력손실을 보이는 자연발증 마우스의 생물학적 특성
대한이비인후-두경부외과학회지
2004 .01
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UCI(KEPA) : I410-ECN-0101-2009-510-015712972