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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 659 - 667 (9page)
이용수
초록· 키워드
오류제보하기
Mycobacterium tuberculosis or its secreted protein antigens are known as a potent inducer of maturation process of dendritic cells, during which the expression of cell surface molecules and the capability of antigen presentation are increased, resulting in potent interaction with T cells to initiate the acquired immune response against tuberculosis. In this study, the cell wall-associated Triton X-100 soluble protein (TSP) antigens, TSP- BCG, TSP-H37Ra, TSP- H37Rv and TSP-K, were tested on murine bone marrowderived dendritic cells to determine the capability of their immunologic modulation. Only TSP-H37Rv stimulated murine dendritic cells showed moderate production of IL-6 and MIP-1α compared to those of LPS. TSP-H37Rv antigen did not induce the production of IL-12, TNF-α or IL-10. Other TSP antigenstimulated murine dendritic cells showed minimal or no induction of cytokines (IL-6, IL-12, TNF-α or IL-10) or chemokines (MIP-1α or RANTES). The murine dendritic cells showed the production of NO as well as the expression of iNOS mRNA after LPS stimulation, however, none of TSP antigen-stimulated murine dendritic cells induced either NO or iNOS mRNA expression. The allostimulation of T cells by murine dendritic cells, which were stimulated with each TSP antigens, showed insignificant increase in T cell proliferation activity in mixed lymphocyte reaction. These results suggested that cell wall-associated TSP antigen isolated from Mycobacterium tuberculosis H37Rv strain acts as a more potent stimulator on murine dendritic cells than any other TSP antigens, even the stimulation from TSP-H37Rv was not enough to activate the maturation of process of murine dendritic cells.
목차
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Banchereau, J. / 1998 / Dendritic cells and the control of immunity / Nature 392 : 245 ~ 252
2. [학술지(정기간행물)] - Barnes, P.F. / 1989 / Characterization of T cell antigens associated with the cell wall protein-peptidoglygan complex of Mycobacterium tuberculosis / J. Immunol 143 : 2656 ~ 2662
3. [학술지(정기간행물)] - Beatty, W.L. / 2000 / Identification of mycrobacterial surface proteins released into subcellular compartments of infected macrophages / Infect. Immun 68 : 6997 ~ 7002
4. [학술지(정기간행물)] - Bodnar, K.A. / 2001 / Fate of Mycobacterium tuberculosis within Murine Dendritic Cells / Infect. Immun 69 : 800 ~ 809
5. [학술지(정기간행물)] - Brightbill, H.D. / 1999 / Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors / Science 285 : 732 ~ 736
2. [학술지(정기간행물)] - Barnes, P.F. / 1989 / Characterization of T cell antigens associated with the cell wall protein-peptidoglygan complex of Mycobacterium tuberculosis / J. Immunol 143 : 2656 ~ 2662
3. [학술지(정기간행물)] - Beatty, W.L. / 2000 / Identification of mycrobacterial surface proteins released into subcellular compartments of infected macrophages / Infect. Immun 68 : 6997 ~ 7002
4. [학술지(정기간행물)] - Bodnar, K.A. / 2001 / Fate of Mycobacterium tuberculosis within Murine Dendritic Cells / Infect. Immun 69 : 800 ~ 809
5. [학술지(정기간행물)] - Brightbill, H.D. / 1999 / Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors / Science 285 : 732 ~ 736
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UCI(KEPA) : I410-ECN-0101-2009-510-015707171