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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.9
- 수록면
- 399 - 404 (6page)
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Atopic dermatitis and asthma are common chronic inflammatory diseases. A pivotal role of IL-4 in airway inflammation has been elucidated by studying mice in which IL-4 was genetically disrupted. However, there have been no trials to examine the effect of IL-4 dysfunction on skin inflammation. Thus, the aim of this study was to investigate the role of IL-4 in skin inflammation using IL-4<SUP>-/-</SUP> mice. To induce skin inflammation, a 15% phthalic anhydride solution was repeatedly applied to the dorsal surfaces of the ears of both IL-4<SUP>-/-</SUP> and BALB/c mice for 5 weeks. After treatment, skin inflammation-related factors were detected in the ear tissue, lymph nodes, spleens, and sera of the mice. Ear thicknesses and weights of the auricular lymph nodes, indicating the degree of skin inflammation, were significantly smaller in IL-4<SUP>-/-</SUP> mice than in BALB/c mice. Immunoglobulin E concentrations in sera were also significantly lower in IL-4<SUP>-/-</SUP> mice. In cytokine secretion profiles, expression levels of inflammation-inducing cytokines and chemokines, such as IL-6, IL-10, IL-13, KC, MCP-1 and VEGF were lower in IL-4<SUP>-/-</SUP> mice than in BALB/c. These findings suggest that knock-out of IL-4 relieves allergen-induced skin inflammation. Thus, the modulation of IL-4 expression may provide important insights into therapeutic targets of chronic skin inflammatory diseases, such as atopic dermatitis.
목차
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (17)
참고문헌 신청
1. [학술지(정기간행물)] - Ban, M. / 2001 / Relationship between IgE positive cell numbers and serum total IgE levels in mice treated with trimellitic anhydride and dinitrochlorobenzene / Toxicol. Lett 118 : 129 ~ 137
2. [학술지(정기간행물)] - Chan, L.S. / 2001 / Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopic dermatitis / J. Invest. Dermatol 117 (4) : 977 ~ 983
3. [학술지(정기간행물)] - Conrad, D.H. / 1987 / Effect of B cell stimulatory factor-1 (interleukin 4) on Fcε and FceRII receptor expression on murine B lymphocytes and B cell lines / J. Immunol 139 : 2290 ~ 2296
4. [학술지(정기간행물)] - Dearman, R.J. / 1996 / Characterization of chemical allergens as a function of divergent cytokine secretion profiles induced in mice / Toxicol. Appl. Pharmacol 138 : 308 ~ 316
5. [학술지(정기간행물)] - Glimcher, L.H. / 2000 / Lineage commitment in the immune system: the T helper lymphocyte grows up / Genes Dev 14 : 1693 ~ 1711
2. [학술지(정기간행물)] - Chan, L.S. / 2001 / Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopic dermatitis / J. Invest. Dermatol 117 (4) : 977 ~ 983
3. [학술지(정기간행물)] - Conrad, D.H. / 1987 / Effect of B cell stimulatory factor-1 (interleukin 4) on Fcε and FceRII receptor expression on murine B lymphocytes and B cell lines / J. Immunol 139 : 2290 ~ 2296
4. [학술지(정기간행물)] - Dearman, R.J. / 1996 / Characterization of chemical allergens as a function of divergent cytokine secretion profiles induced in mice / Toxicol. Appl. Pharmacol 138 : 308 ~ 316
5. [학술지(정기간행물)] - Glimcher, L.H. / 2000 / Lineage commitment in the immune system: the T helper lymphocyte grows up / Genes Dev 14 : 1693 ~ 1711
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