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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
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- 2012.3
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- 19 - 24 (6page)
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In the present study, toxicity of silver nanoparticles (AgNPs) was investigated in the nematode, Caenohabditis elegans focusing on the upstream signaling pathway responsible for regulating oxidative stress, such as mitogen-activated protein kinase (MAPK) cascades. Formation of reactive oxygen species (ROS) was observed in AgNPs exposed C.elegans, suggesting oxidative stress as an important mechanism in the toxicity of AgNPs towards C. elegans. Expression of genes in MAPK signaling pathways increased by AgNPs exposure in less than 2-fold compared to the control in wildtype C.elegans, however, those were increased dramatically in sod-3 (gk235) mutant after 48 h exposure of AgNPs (i.e. 4-fold for jnk-1 and mpk-2; 6-fold for nsy-1, sek-1, and pmk-1, and 10-fold for jkk-1). These results on the expression of oxidative stress response genes suggest that sod-3 gene expression appears to be dependent on p38 MAPK activation. The high expressions of the pmk-1 gene 48 h exposure to AgNPs in the sod-3 (gk235) mutant can also be interpreted as compensatory mechanisms in the absence of important stress response genes. Overall results suggest that MAPK-based integrated stress signaling network seems to be involved in defense to AgNPs exposure in C.elegans.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGMENT
REFERENCES
참고문헌 (20)
참고문헌 신청
AshaRani, P. V. / 2009 / Cytotoxicity and genotoxicity of silver nanoparticles in human cells / ACS Nano 3:279~290
Back, P. / 2010 / Effects of sod gene overexpression and deletion mutation on the expression profiles of reporter genes of major detoxification pathways in Caenorhabditis elegans / Exp. Gerontol 45:603~610
Bae, E. / 2010 / Bacterial Cytotoxicity of the Silver Nanoparticle Related to Physicochemical Metrics and Agglomeration Properties / Environ. Toxicol. Chem 29:2154~2160
Brenner, S / 1974 / The genetics of Caenorhabditis elegans / Genetics 77:71~94
Campbell, F.W / 2010 / The use of nanoparticles in electroanalysis: an updated review / Anal. Bioanal. Chem 396:241~259
Back, P. / 2010 / Effects of sod gene overexpression and deletion mutation on the expression profiles of reporter genes of major detoxification pathways in Caenorhabditis elegans / Exp. Gerontol 45:603~610
Bae, E. / 2010 / Bacterial Cytotoxicity of the Silver Nanoparticle Related to Physicochemical Metrics and Agglomeration Properties / Environ. Toxicol. Chem 29:2154~2160
Brenner, S / 1974 / The genetics of Caenorhabditis elegans / Genetics 77:71~94
Campbell, F.W / 2010 / The use of nanoparticles in electroanalysis: an updated review / Anal. Bioanal. Chem 396:241~259
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