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자료유형
학술저널
저자정보
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.32 No.3
발행연도
2008.9
수록면
220 - 225 (6page)

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The present investigation was performed to evaluate the homeostatic regulation of sleep architecture by the ethanolextract of Korea red ginseng (KRG), since the available data were often controversial. In addition, it was also interested in whether the sleep-wake stages were differently affected by low and high doses of KRG. Each adult Wistar male rat was implanted with a transmitter for recording EEG and activity via telemetry. After one week of surgery, polygraphic signs of undisturbed sleep-wake activities were recorded for 12 h (between 9:00 am and 9:00 pm) after KRG administration. KRG (10 and 100 ㎎/㎏) increased non-rapid eye movement (NREM) sleep as well as total sleep. The total percentages of wakefulness were decreased comparably. KRG (10 ㎎/㎏) decreased the power density of the δ-wave (0.75-4.5 ㎐) and increased α-wave (8.0-13.0 ㎐) in the NREM and rapid eye movement (REM) sleep. KRG also decreased δ-wave power density in wake time. However, KRG (100 ㎎/㎏) increased δ-wave and decreased θ-wave (5.0-9.0 ㎐) power density in wake time, while showed little effect on the power density in NREM and REM sleep. In conclusion, low and high doses of KRG increase spontaneous sleep and NREM sleep and differently regulate the EEG spectra in REM and NREM sleep.

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Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENT
REFERENCES

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