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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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This study was conducted to investigate the effect of an anti-inflammatory and analgesic action of the glucosamine HCl (Glucosamine) and SH-1 (Glucosamine + Oriental herbal composition combined group). Male sprague-Dawley rats (200~250 g) and ICR mice (20~30 g) were randomized and these experimental groups were divided into 4 groups. Two control group were given as negative control (saline) and positive control (Ibuprofen, 100 ㎎/㎏) and two groups given as oral administration of Glucosamine (320 m/㎏) and SH-1. Carrageenan induced paw edema test, hot plate method, croton oil induced granuloma, capillary permeability test and acetic acid writhing syndrome were also shown to be comparable in the SH-1 group to anti-inflammatory drug group such as positive control group (Ibuprofen). Although further studies should be performed to confirm the effects of SH-1, present results suggest that the combined administration of SH-1 have potential action in anti-inflammatory and analgesic action. It could be applicable for the improvement of arthritic symptoms as a new diet-supplement.
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REFERENCES
참고문헌 (18)
참고문헌 신청
1. [학술지(정기간행물)] - Bonney RJ / 1978 / Mononuclear phagocytes from carrageenan-induce granulomas. Isolation, cultivation, and characterization / J Exp Med 148 : 261 ~ 275
2. [학술지(정기간행물)] - Crolle G / 1980 / Glucosamine sulphate for the management of arthrosis: a controlled clinical investigation / Curr Med Res Opin 7 : 104 ~ 109
3. [학술지(정기간행물)] - Ishikawa H / 1968 / Studies on the mode of action of anti-inflammatory agents. I. Quantitative analysis of antiinflammatory effects by carboxymethyl cellulose pouch method / Yakugaku Zasshi 88 : 1472 ~ 1477
4. [학술지(정기간행물)] - 정춘식 / 2003 / 홍삼추출물과 글루코사민 복합제제의 관절염에 미치는 영향 / 생약학회지 34 (4) : 327 ~ 334
5. [학술지(정기간행물)] - Kim OK / 1999 / Effects of Glucosamine Hydrochloride, Taurine and Their Combined administration on Anti-inflammatory and Analgesic Action in Rats / J Kor Soc Food Sci Nutr 28 : 1113 ~ 1123
2. [학술지(정기간행물)] - Crolle G / 1980 / Glucosamine sulphate for the management of arthrosis: a controlled clinical investigation / Curr Med Res Opin 7 : 104 ~ 109
3. [학술지(정기간행물)] - Ishikawa H / 1968 / Studies on the mode of action of anti-inflammatory agents. I. Quantitative analysis of antiinflammatory effects by carboxymethyl cellulose pouch method / Yakugaku Zasshi 88 : 1472 ~ 1477
4. [학술지(정기간행물)] - 정춘식 / 2003 / 홍삼추출물과 글루코사민 복합제제의 관절염에 미치는 영향 / 생약학회지 34 (4) : 327 ~ 334
5. [학술지(정기간행물)] - Kim OK / 1999 / Effects of Glucosamine Hydrochloride, Taurine and Their Combined administration on Anti-inflammatory and Analgesic Action in Rats / J Kor Soc Food Sci Nutr 28 : 1113 ~ 1123
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