지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The aim of this study was to reduce the side effects and to develop effective drugs using bucillamine (B), lornoxicam (L), and its mixtures on the analgesic and anti-inflammatory effects. With this goal, we compared their effects on the four different mixtures with a sole treatment (B 40 mg/kg and L 1.60 mg/kg). The mixture 1, 2, 3, and 4 ratios of B to L (mg/kg) were 20 to 0.80, 40 to 1.60, 80 to 3.20, and 40 to 1.14, respectively. In terms of acetic acid-induced vascular permeability, B and L inhibited the amount of dye leakage approximately 37.8 and 66.5%, respectively. And mixture 1, 2 and 3 showed inhibition of 47.4%, 81.5%, and 84.3%. The mixture 4 inhibited approximately 49.4%. In carrageenan- induced paw edema model, mixtures of B and L effectively inhibited paw edema measured 1/2~3 hours after carrageenan injection. Especially, mixture 2 inhibited 50.7%, 52.7%, 50.9% of paw edema after 1, 2, and 3 hr, significantly. We also examined an analgesic effect using the writhing test. In terms of the acetic acid-induced writhing syndrome, the control group showed writhing syndrome 18.5 times. B and L showed 9 and 6.3 times, inhibiting 51.6% and 65.9% respectively. And aspirin, as a positive control drug, showed the 7.1 times writhing syndrome. The mixture 1, 2, 3, and 4 also significantly inhibited the writhing syndrome to 62.2%, 93.0%, 51.4%, and 77.8%, respectively. From these results, we could suggest that the range of B and L ratio of 25 : 1 to 35 : 1 may be applicable to developing analgesic and anti-inflammatory drugs.
목차
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참고문헌 (20)
참고문헌 신청
Tizard, I. R / 1986 / An introduction of inflammation, Immunology, 2nd ed / Saunders College Publishing, Philadelphia :432~441
Land, W. E / 1985 / Mechanisms of action of anti-inflammatory drugs. Advan. Drug. Res / Academic Press, London :14~147
Samuelsson, B / 1979 / Pathways of arachidonic acid metabolism. Advan. Inflamm. Res / Raven Press, New York :405~412
Brent, R. L / 2001 / Teratogen update: reproductive risks of leflunomide (Arava); a pyrimidine synthesis inhibitor: counseling women taking leflunomide before or during pregnancy and men taking leflunomide who are contemplating fathering a child / Teratology 63:106
Weinblatt, M. E / 2000 / Serious liver disease in a patient receiving methotrexate and leflunomide / Arthritis Rheum 43:2609
Land, W. E / 1985 / Mechanisms of action of anti-inflammatory drugs. Advan. Drug. Res / Academic Press, London :14~147
Samuelsson, B / 1979 / Pathways of arachidonic acid metabolism. Advan. Inflamm. Res / Raven Press, New York :405~412
Brent, R. L / 2001 / Teratogen update: reproductive risks of leflunomide (Arava); a pyrimidine synthesis inhibitor: counseling women taking leflunomide before or during pregnancy and men taking leflunomide who are contemplating fathering a child / Teratology 63:106
Weinblatt, M. E / 2000 / Serious liver disease in a patient receiving methotrexate and leflunomide / Arthritis Rheum 43:2609
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