지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 39 - 44 (6page)
이용수
초록· 키워드
오류제보하기
The effects of β-glucan from Aureobasidium pullulans SM-2001 were observed on the rat rib fracture healing. 31.25, 62.5 and 125 ㎎/㎏ of β-glucan were orally administered once a day for 13 days to ribfractured rats from 6 h after operation, and changes on the volume, mineral density, strength and histopathology of callus were observed. The effects of β-glucan were compared with 10 ㎍/㎏ of human parathyroid hormone 1-34 (hPTH) subcutaneously treated group. Treatment of β-glucan induced dosedependent increases on the callus mineral density and strength with dramatical decreases on the callus volume. In addition, more active cartilaginous ossifications were observed in β-glucan treated groups as compared with rib-fractured control; hence, the callus connective tissues and cartilaginous tissues were decreased, and consequently, osteoid tissues in callus were dramatically increased at histopathological observation. It is, therefore, concluded that β-glucan used in the present study accelerated the fracture healing, especially on the ossification. 125 ㎎/㎏ of β-glucan shows similar or slight lower effects on accelerating facture healing as compared with hPTH 10 ㎍/㎏.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (40)
참고문헌 신청
1. [학술지(정기간행물)] - Adolphson, P / 2000 / Clodronate increases mineralization of callus after Colles' fracture: a randomized, double-blind, placebo-controlled, prospective trial in 32 patients / Acta Orthop. Scand 71 : 195 ~ 200
2. [학술지(정기간행물)] - Aleksyniene, R / 2004 / Parathyroid hormonepossible future drug for orthopedic surgery / Medicina (Kaunas) 40 : 842 ~ 849
3. [학술지(정기간행물)] - Amanat, N / 2005 / A single systemic dose of pamidronate improves bone mineral content and accelerates restoration of strength in a rat model of fracture repair / J. Orthop. Res 23 : 1029 ~ 1034
4. [학술지(정기간행물)] - Andreassen, T.T / 2001 / Increases in callus formation and mechanical strength of healing fractures in old rats treated with parathyroid hormone / Acta Orthop. Scand 72 : 304 ~ 207
5. [학술지(정기간행물)] - Bilston, L.E / 2002 / Zoledronic acid improves the mechanical properties of normal and healing bone / Clin. Biomech 17 : 716 ~ 718
2. [학술지(정기간행물)] - Aleksyniene, R / 2004 / Parathyroid hormonepossible future drug for orthopedic surgery / Medicina (Kaunas) 40 : 842 ~ 849
3. [학술지(정기간행물)] - Amanat, N / 2005 / A single systemic dose of pamidronate improves bone mineral content and accelerates restoration of strength in a rat model of fracture repair / J. Orthop. Res 23 : 1029 ~ 1034
4. [학술지(정기간행물)] - Andreassen, T.T / 2001 / Increases in callus formation and mechanical strength of healing fractures in old rats treated with parathyroid hormone / Acta Orthop. Scand 72 : 304 ~ 207
5. [학술지(정기간행물)] - Bilston, L.E / 2002 / Zoledronic acid improves the mechanical properties of normal and healing bone / Clin. Biomech 17 : 716 ~ 718
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UCI(KEPA) : I410-ECN-0101-2009-510-014753524