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자료유형
학술저널
저자정보
Vetvicka, Vaclav (Department of Pathology, University of Louisville) Vetvickova, Jana (Department of Pathology, University of Louisville)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제11권 제3호
발행연도
2011.1
수록면
169 - 175 (7page)

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Numerous types of ${\beta}$(1-3)-D-glucans have been isolated from almost every species of yeast, grain, and fungi. These products have been extensively studied for their immunological and pharmacological effects. In this paper we evaluated the possibility whether individual ${\beta}$(1-3)-D-glucans will have an activity in less studied areas such as adipogenesis and inflammation. Our results showed that of the tested ${\beta}$(1-3)-D-glucans, yeast-derived insoluble Glucan #300, strongly inhibited adipogenic differentiation, supported wound healing and significantly lowered skin irritation. The remaining ${\beta}$(1-3)-D-glucans were significantly less active. Taken together, our study showed that with respect to natural ${\beta}$(1-3)-D-glucans, there is a clear yes-or-no effect suggesting that highly purified and highly active ${\beta}$(1-3)-D-glucans will have pleiotropic biological impact, whereas poorly isolated and/or less active ${\beta}$(1-3)-D-glucans will have only mediocre properties.

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