지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 73 - 78 (6page)
이용수
초록· 키워드
오류제보하기
Red ginseng acidic polysaccharide (RGAP), isolated from Korean red ginseng (Panax ginseng C.A. Meyer), has been shown to have a variety of biological functions such as immunostimulating and anti-tumor activities. In the present study, we investigated whether RGAP inhibited ligand-induced platelet aggregation. The washed platelet-rich plasma was prepared from male SD rats with successive centrifugation. The platelets (10?/ml) were preincubated with 1 mM of CaCl₂for 2 min either in the presence or in the absence of RGAP (10 ~ 50 ㎍/ml) and were stimulated with collagen (2.5 ㎍/ml) and thrombin (0.1 U/ml). RGAP dose-dependently inhibited thrombin-induced platelet aggregation with IC<SUB>50</SUB> value of 26.2±2.0 ㎍/ml. In collagen-induced platelet aggregation, RGAP inhibited the reaction with an IC<SUB>50</SUB> value of 31.5±3.0 ㎍/ml. RGAP potently suppressed the intracellular calcium ion, which was stimulated by thrombin (0.1 U/ml). Among mitogen-activated protein kinase (MAPK) subtypes, the extracellular signal-regulated kinase (ERK) 1/2 and p38 MAPK were analyzed in the present study. RGAP inhibited the phosphorylation of ERK2 and p38 MAPK, which was activated by collagen (2.5 ㎍/ml). Finally, these results suggested that besides saponin fraction, RGAP take an important role in the preventive effect of Korean red ginseng against cardiovascular disease such as thrombosis and atherosclerosis.
목차
Abstract
INTRODUCTION
MATERIALS & METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (39)
참고문헌 신청
1. [학술지(정기간행물)] - Maguire,P.B / 2004 / Application of proteomics to the study of platelet regulatory mechanisms / Trends Cardiovasc Med 14 : 207 ~ 220
2. [학술지(정기간행물)] - Huo,Y / 2001 / Adhesion molecules and atherogenesis / Acta Physiol Scand 173 : 35 ~ 43
3. [학술지(정기간행물)] - Lindemann,S / 2007 / The active platelet: translation and protein synthesis in an anucleate cell / Semin Thromb Hemost 33 : 144 ~ 150
4. [학술지(정기간행물)] - Macaulay,I.C / 2005 / Platelet genomics and proteomics in human health and disease / J Clin Invest 115 : 3370 ~ 3377
5. [학술지(정기간행물)] - Lee,J.J / 2006 / Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization / Vascul Pharmacol 45 : 148 ~ 153
2. [학술지(정기간행물)] - Huo,Y / 2001 / Adhesion molecules and atherogenesis / Acta Physiol Scand 173 : 35 ~ 43
3. [학술지(정기간행물)] - Lindemann,S / 2007 / The active platelet: translation and protein synthesis in an anucleate cell / Semin Thromb Hemost 33 : 144 ~ 150
4. [학술지(정기간행물)] - Macaulay,I.C / 2005 / Platelet genomics and proteomics in human health and disease / J Clin Invest 115 : 3370 ~ 3377
5. [학술지(정기간행물)] - Lee,J.J / 2006 / Antiplatelet activity of carnosol is mediated by the inhibition of TXA2 receptor and cytosolic calcium mobilization / Vascul Pharmacol 45 : 148 ~ 153
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Anti-hyperlipidemic Effects of Red Ginseng Acidic Polysaccharide from Korean Red Ginseng
고려인삼학회 학술대회
2010 .05
-
Immuno-stimulating activities of 4 years and 6 years red ginseng acidic polysaccharide
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Immunomodulatory effects of Red ginseng acidic polysaccharide (RGAP) and non‐saponin red ginseng components (NSRG) on innate immune cells
고려인삼학회 학술대회
2009 .12
-
Synergistic Antitumor Effect of Red Ginseng Acidic Polysaccharide(RGAP) and Paclitaxel(Taxol)
대한약학회 학술대회
2001 .01
-
한국산 및 외국산 홍삼의 사포닌 및 무기물 성분 비교
Journal of Ginseng Research
2002 .09
-
홍삼과 백삼의 비교 고찰
Journal of Ginseng Research
2005 .03
-
Inhibitory effects of total saponin from Korean Red Ginseng on [Ca2+]i mobilization through phosphorylation of cyclic adenosine monophosphate-dependent protein kinase catalytic subunit and inositol 1,4,5-trisphosphate receptor type I in human platelets
Journal of Ginseng Research
2015 .10
-
Physiological and pharmacological features of the non-saponin components in Korean Red Ginseng
Journal of Ginseng Research
2020 .07
-
Inhibitory Effects of Water Extract from Rice Bran Due to cAMP-dependent Phosphorylation of VASP (Ser157) on ADP-induced Platelet Aggregation
대한의생명과학회지
2014 .09
-
홍삼박으로부터 산성다당체의 추출조건 조사
Journal of Ginseng Research
2002 .09
-
홍삼에 함유된 갈변물질 및 산성다당체에 대한 연구현황
Journal of Ginseng Research
2006 .03
-
The effect of extrusion conditions on the acidic polysaccharide, ginsenoside contents and antioxidant properties of extruded Korean red ginseng
Journal of Ginseng Research
2013 .04
-
Inhibitory Effects of Rice Bran Water Extract Fermented Lactobacillus plantarum due to cAMP-dependent Phosphorylation of VASP (Ser157) on human Platelet Aggregation
대한의생명과학회지
2015 .06
-
The contents of ginsenosides and amino sugars in red ginseng, inside white red ginseng, and inside and outside white red ginseng
고려인삼학회 학술대회
2009 .12
-
Clinical Effects of Korean Ginseng, Korean Red Ginseng, Chinese Ginseng, and American Ginseng on Blood Pressure in Mild Hypertensive Subjects
대한한의학회지
2006 .12
-
Acidic polysaccharide of panax ginseng regulates the mitochondria/caspase-dependent apoptotic pathway in radiation-induced damage to the jejunum in mice
한국실험동물학회 학술발표대회 논문집
2014 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2010-524-001398250