지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: Galgeun-tang (GGT, gegen-tang, kakkon-to), an herbal formula, is used to treat the common cold, fevers, headaches, hangovers and neck and upper back stiffness. The drugs currently used to treat atopic dermatitis (AD) are limited by the significant adverse effects associated with their long-term usage. The need to efficiently manage the AD response while reducing side effects has led to the development of alternative remedies.
Methods: To assess the effects of GGT on AD, the anti-inflammatory and anti-AD properties of GGT were evaluated in both in vitro and in vivo systems.
Results: Nitric oxide (NO) and histamine production on lipopolysaccharide (LPS)-treated RAW264.7 cells and phorbol-12 myristate 13-acetate (PMA)/A23187-treated MC/9 cells, respectively, were inhibited by GGT. GGT reduced thymus and activation-regulated chemokine (TARC/CCL17) release on TNF-α/IFN-γ stimulated HaCaT cells in a dose-dependent manner. GGT reduced both plasma levels of IgE and histamine and the dermatitis score in house dust mite induced atopic dermatitis-like lesions on NC/Nga mice. However, there were no significant histopathological differences observed between the GGT group and the AD-induced group, such as AD-like lesions in the dorsal skin or ear or mast cell infiltration in the dorsal skin.
Conclusions: These results indicate that GGT inhibits chemokine production by keratinocytes and the atopic dermatitis response in NC/Nga mice, suggesting that GGT may be useful as a therapeutic remedy for treating AD and allergic inflammation-related diseases.
Methods: To assess the effects of GGT on AD, the anti-inflammatory and anti-AD properties of GGT were evaluated in both in vitro and in vivo systems.
Results: Nitric oxide (NO) and histamine production on lipopolysaccharide (LPS)-treated RAW264.7 cells and phorbol-12 myristate 13-acetate (PMA)/A23187-treated MC/9 cells, respectively, were inhibited by GGT. GGT reduced thymus and activation-regulated chemokine (TARC/CCL17) release on TNF-α/IFN-γ stimulated HaCaT cells in a dose-dependent manner. GGT reduced both plasma levels of IgE and histamine and the dermatitis score in house dust mite induced atopic dermatitis-like lesions on NC/Nga mice. However, there were no significant histopathological differences observed between the GGT group and the AD-induced group, such as AD-like lesions in the dorsal skin or ear or mast cell infiltration in the dorsal skin.
Conclusions: These results indicate that GGT inhibits chemokine production by keratinocytes and the atopic dermatitis response in NC/Nga mice, suggesting that GGT may be useful as a therapeutic remedy for treating AD and allergic inflammation-related diseases.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusions
References
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Terui T / 2009 / Analysis of the mechanism for thedevelopment of allergic skin inflammation andthe application for its treatment: overview of thepathophysiology of atopic dermatitis / JPharmacol Sci 110 (3) : 232 ~ 236
2. [학술지(정기간행물)] - Nagai H / 2006 / Recentadvances in the development of anti-allergicdrugs / Allergol Int 55 (1) : 35 ~ 42
3. [학술지(정기간행물)] - Aoyama H / 1995 / Successful treatment of resistantfacial lesions of atopic dermatitis with 0.1%FK506 ointment / Br J Dermatol 133 (3) : 494 ~ 496
4. [학술지(정기간행물)] - Hanifin JM / 2004 / Guidelines ofcare for atopic dermatitis, developed inaccordance with the American Academy ofDermatology (AAD)/American Academy ofDermatology Association AdministrativeRegulations for Evidence-Based Clinical PracticeGuidelines / J Am Acad Dermatol 50 (3) : 391 ~ 404
5. [학술지(정기간행물)] - Boguniewicz M / 1998 / Arandomized, vehicle-controlled trial oftacrolimus ointment for treatment of atopicdermatitis in children. Pediatric TacrolimusStudy Group / J Allergy Clin Immunol 102 (1) : 637 ~ 644
2. [학술지(정기간행물)] - Nagai H / 2006 / Recentadvances in the development of anti-allergicdrugs / Allergol Int 55 (1) : 35 ~ 42
3. [학술지(정기간행물)] - Aoyama H / 1995 / Successful treatment of resistantfacial lesions of atopic dermatitis with 0.1%FK506 ointment / Br J Dermatol 133 (3) : 494 ~ 496
4. [학술지(정기간행물)] - Hanifin JM / 2004 / Guidelines ofcare for atopic dermatitis, developed inaccordance with the American Academy ofDermatology (AAD)/American Academy ofDermatology Association AdministrativeRegulations for Evidence-Based Clinical PracticeGuidelines / J Am Acad Dermatol 50 (3) : 391 ~ 404
5. [학술지(정기간행물)] - Boguniewicz M / 1998 / Arandomized, vehicle-controlled trial oftacrolimus ointment for treatment of atopicdermatitis in children. Pediatric TacrolimusStudy Group / J Allergy Clin Immunol 102 (1) : 637 ~ 644
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UCI(KEPA) : I410-ECN-0101-2015-510-001301275