지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2005.6
- 수록면
- 207 - 215 (9page)
이용수
이 논문의 연구 히스토리 (4)
2004
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Recently, the dysfunction of hepatocytes is associated with the development of diabetes mellitus. Cell proliferation is regulated by diverse growth factors. Among them, insulin like growth factors (IGFs) arc also involved in the pathogenesis of diabetes mellitus. In addition, protein kinase C (PKC) activation and oxidative stress are implicated to the pathogenesis of diabetes mellitus. However, it is not yet known about the effect of high glucose on IGF-Ⅰ and IGF-Ⅱ secretion and its related signal pathways in the hepatocytes, Thus, we examined the mechanisms by which high glucose regulates secretion of IGFs in hepatocytes, In the present study, high glucose inhibited IGF-Ⅰ secretion but increased IGF-Ⅱ secretion in a dose (＞15 mM) and time (＞8 hr) dependent manner in hepatocytes. These effects were also prevented by antioxidants (N-acetyl cystine, taurine, GSH), suggesting the role of oxidative stress. High glucose also increased lipid peroxide (LPO) formation, which was prevented by antioxidants. Furthermore, we examined the involvement of PKC. The pretreatment of PKC inhibitors (staurosporine, H-7, bisindolylmaleimide Ⅰ) blocked high glucose-induced decrease of IGF-Ⅰ secretion and increase of IGF-Ⅱ secretion and LPO formation. These results suggest that PKC activation triggers high glucose-induced alteration of IGF-Ⅰ and IGF-Ⅱ secretion and is responsible for the high glucose-induced increase of oxidative stress. In conclusion, high glucose activates PKC-oxidative stress signal cascade, which decreases IGF-Ⅰ secretion but increases IGF-Ⅱ secretion in hepatocytes.
목차
서론
재료 및 방법
결과
고찰
결론
감사의 글
참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hepatocyte에서 고포도당에 의한 IGFs 분비와 PKC 및 산화성 스트레스와의 관련성에 관한 연구
Laboratory Animal Research
2004 .12
-
The Regulation of Insulin-Like Growth (IGF) Factors and IGF Binding Proteins by High Glucose in Mesangial Cells
대한의생명과학회지
2004 .09
-
The Signaling Pathways Involved in High Glucose-Induced Secretion of Insulin-Like Growth Factors (IGFs) and IGF Binding Proteins in Podocytes
대한의생명과학회지
2006 .09
-
High glucose alters Insulin-like Growth factor -Ⅰ and -Ⅱ Secretion via PKC-oxidative stress in Rat Hepatocytes
한국실험동물학회 학술발표대회 논문집
2005 .06
-
신장 근위세뇨관 세포에서 고포도다에 의한 IGF-I 분비 촉진작용에 있어서 인삼의 차단효과
Journal of Ginseng Research
2009 .03
-
한국 소아 및 청소년에서 혈중 유리 insulin-like growth factor-I 농도치와 임상적 의의
Clinical and Experimental Pediatrics
2008 .01
-
The Effect of Insulin-like Grow Factor-I on Cell Proliferation and its Related Signal Pathways in Primary Cultured Rat Hepatocytes
Laboratory Animal Research
2006 .09
-
Insulin-like Growth Factor Systems의 생식기능에서의 역할;자궁편
대한불임학회잡지
1996 .01
-
Metformin Down-regulates Endometrial Carcinoma Cell Secretion of IGF-1 and Expression of IGF-1R
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
The Effects of Insulin-like Growth Factor-I (IGF-I) in Mouse Lung Cancer Cells
Cancer Research and Treatment
2002 .01
-
사람 난소발생에 있어서 IGF2 유전자의 역할
해부·생물인류학
1996 .12
-
Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus
Annals of Pediatirc Endocrinology & Metabolism
2015 .01
-
Ethanol이 배양된 흰쥐의 간세포에서 Insulin-like growth factor-Ⅰ (IGF-Ⅰ)와 Insulin-like growth factor binding protein-1 (IGFBP-1) 분비에 미치는 효과 : Lipid peroxides (LPO) 활성과의 관련성
Laboratory Animal Research
2004 .12
-
월경 주기에 따른 IGF-I과 -II의 혈중농도와 난소에서의 발현
Obstetrics & Gynecology Science
2006 .01
-
마우스 섬유아세포(3T3 fibroblast cells)에서 Insulin-like Growth Factor-I(IGF-I) 및 IGF Binding Protein-3 (IGFBP-3)이 세포증식에 미치는 영향
Tuberculosis and Respiratory Diseases
1999 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-510-016368305