지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.9
- 수록면
- 217 - 224 (8page)
이용수
초록· 키워드
오류제보하기
It has been reported that the dysfunctions of podocytes are associated with the development of diabetic nephropathy. In addition, insulin-like growth factors (IGFs) are associated with the development of diabetic nephropathy. However, it is not yet known about the effect of high glucose on IGF-I, -II secretion, and IGF binding proteins (IGFBPs) expression in the podocytes. Thus, this study was conducted to examine the effect of high glucose on IGF system and its involvement of protein kinase C (PKC) and mitogen activated protein kinases (MAPKs) in podocytes. In this study, high glucose (25 mM) increased IGF-I and IGF-II secretion (P＜0.05), which was blocked by SB 203580 (a p38 MAPK inhibitor) but not by PD 98059 (a p44/42 MAPK inhibitor). In addition, high glucose-induced stimulation of IGFs was blocked by bisindolylmaleimide I and staurosporine (protein kinase C inhibitors). High glucose also increased IGFBP-1 expression, which was blocked by bisindolylmaleimide I and SB 203580. In conclusion, high glucose alters IGFs secretion and IGFBP expression via PKC and p38 MAPK pathways in podocytes.
목차
영어초록
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (37)
참고문헌 신청
[학술지(정기간행물)] - RR,Bowsher / 1991 / Measurement of insulin-like growth factor-II in physiological fluids and tissues. I. An improved extraction procedure and radioimmunoassay for human and rat fluids / Endocrinology 128 : 805 ~ 814
[학술지(정기간행물)] - DJ,Bridgewater / 2005 / Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway / Kidney Int. 67 : 1208 ~ 1314
[학술지(정기간행물)] - DJ,Bridgewater / 2003 / Insulin-like growth factor binding protein-2 modulates podocyte mitogenesis / Pediatr Nephrol. 18 : 1109 ~ 1115
[학술지(정기간행물)] - PF,Collett-Solberg / 2000 / Genetics, chemistry, and function of the IGF/IGFBP system / Endocrine 12 : 121 ~ 136
[학술지(정기간행물)] - WH,Daughaday / 1989 / Insulin-like growth factors I and II Peptide messenger ribonucleic acid and gene structure serum, and tissue concentrations / Endocr Rev. 10 : 68 ~ 91
[학술지(정기간행물)] - DJ,Bridgewater / 2005 / Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway / Kidney Int. 67 : 1208 ~ 1314
[학술지(정기간행물)] - DJ,Bridgewater / 2003 / Insulin-like growth factor binding protein-2 modulates podocyte mitogenesis / Pediatr Nephrol. 18 : 1109 ~ 1115
[학술지(정기간행물)] - PF,Collett-Solberg / 2000 / Genetics, chemistry, and function of the IGF/IGFBP system / Endocrine 12 : 121 ~ 136
[학술지(정기간행물)] - WH,Daughaday / 1989 / Insulin-like growth factors I and II Peptide messenger ribonucleic acid and gene structure serum, and tissue concentrations / Endocr Rev. 10 : 68 ~ 91
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UCI(KEPA) : I410-ECN-0101-2009-510-017357328