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Electrical stimulation is assumed to augment the adaptive plasticity of the neighboring brain around the region of stroke and to enhance motor recovery in stroke models. The purpose of this study is to evaluate the effects of anodal cortical stimulation for enhancement of motor recovery in rat stroke model. This study used a photothrombotic model of stroke to examine the behavioral effect of cortical stimulation. Sprague-Dawley rats were trained on a task of single pellet reaching (SPR) before surgery. Photothrombosis was applied on the sensorimotor cortex contralateral to paw predominance using rose bengal dye and cold light. Unipolar electrode was implanted at the border between infarct area and normal brain, followed by anodal continuous low voltage stimulation was delivered for 3 weeks. Daily SPR tasks were performed to evaluate the motor recovery using 'Behavior-Stimulation box'. Anodal electrical stimulation not only prompted earlier start of motor recovery but also improved final recovery. It also eliminated "inflammatory dip" of motor deficit. Low voltage electrical stimulation showed no adverse effect in stroke models. It is concluded that low voltage anodal continuous cortical stimulation can remarkably enhance motor recovery in photothrombotic stroke models.

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UCI(KEPA) : I410-ECN-0101-2009-510-016367797