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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 397 - 400 (4page)
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초록· 키워드
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Leukemia inhibitory factor (LIF) is a multifunctional neuropoietic cytokine involved in neuronal development. Mice with target disruption of the LIF gene are available due to transgenic technology and biotechnology. However, LIF-deficient mice have been reported to be embarrassingly poor in replacement and display awkward colony phenotypes. From total 265 breeds, significantly smaller breeding rate and litter numbers were observed from homozygous male pairs. And LIF-deficient mouse colony did not follow rules of genetics. Both heterozygote male and homozygote male colonies showed significantly higher male birth rate than the hypothetical value. Taken together, epochal improvement in acquiring transgenic animals may be necessary to facilitate large-scale or long-term studies using the LIF-deficient mice. Therefore, better strategies to assure enough numbers of LIF-deficient mice are imminent. In order to achieve this goal, long-term monitoring of the colony has been performed and possible solutions also have been suggested.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
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UCI(KEPA) : I410-ECN-0101-2009-510-016363204