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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 383 - 387 (5page)
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초록· 키워드
오류제보하기
Immunomodulating and antitumor activities of the protein fraction (KM-AS) isolated from Korean mistletoe (KM; Viscum album Coloratum) were investigated in mice. Treatment of KM-AS activated peritoneal macrophages to induce IL-1β in an in vitro experiment, and intravenous (i.v.) administration of KM-AS enhanced natural killer (NK) cell activity against Yac-1 NK-sensitive cells 2 days after administration. An i.v. administration of KM-AS (1 or 1.5 ㎍/mouse) 2 days before tumor inoculation significantly inhibited lung metastases of colon 26-M3.1 cells. The prophylactic effect of 1 ㎍/mouse of KM-AS on lung metastasis was almost the same with that of 100 ㎍/mouse of a water extract of KM (KM-110). Furthermore, multiple administrations of KM-AS given at 3 day-intervals after tumor inoculation led to a significant reduction of lung metastasis and suppression of the growth of B16-BL6 melanoma cells in a spontaneous metastasis model. These results suggest that KM-AS can activate NK cells and macrophages, and its immunomodulating activity contributes to the prophylactic as well as therapeutic inhibition of tumor metastasis.
목차
Materials and Methods
Results
Discussion
References
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UCI(KEPA) : I410-ECN-0101-2009-510-016363188