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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.6
- 수록면
- 181 - 185 (5page)
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초록· 키워드
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We examined the minimal amino acid sequence of bovine lactoferricin (Lfcin-B), a cationic peptide corresponding to residues 17-41 near the N-terminus of bovine lactoferrin, to induce apoptosis in THP-1 human monocytic leukemic cells using synthetic peptides. A synthetic peptide (Lfc-17/29, amino acid sequence; FKCRRWQWRMKKL) consist of 13 amino acids near the N-terminus of Lfcin-B induced cell death in THP-1 cells in a dose-dependent manner, showing apparent apoptotic changes such as hypodiploid forms of genomic DNA and apoptotic DNA fragmentation. However, another synthetic peptide (Lfc-30/41, amino acid sequence; GAPSITCVRRAF) consist of 12 amino acids near the C-terminus of Lfcin-B was inactive. The characteristics of Lfc-17/29-induced apoptosis was entirely identical with that of Lfcin-B-induced apoptosis, with regard to increased apoptosis with reduction of serum concentration, and inhibition of apoptosis by addition of Ca²?/Mg²?-dependent endonuclease inhibitor or antioxidants. In an analysis using various synthetic peptides having the partial sequences of Lfc-17/29, we found that a peptide consist of 10 amino acids (Lfc-17/26, FKCRRWQWRM), corresponding to residues 17-26 near the N-terminus of Lfcin-B, was the minimal sequence of Lfc-17/29 responsible for apoptosis induction in tumor cells.
목차
Introduction
Materials and Methods
Results and Discussion
Acknowledgment
References
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UCI(KEPA) : I410-ECN-0101-2009-510-016362974