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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.6
- 수록면
- 135 - 138 (4page)
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Nitric oxide (NO) is known to be involved in the pathogenesis of colorectal cancer in both rodents and humans. iNOS is responsible for the over production of NO in a variety of parenchymal cells and macrophages. In the present study, we utilized iNOS gene knockout mice to investigate the role of iNOS on chemical-induced colorectal polyposis. Azoxymethane (AOM) at a dose of 10 ㎎/㎏ body weight was administered to male and female iNOS<SUP>-/-</SUP> or iNOS wt C57BL/6J mice once a week for six weeks. The mice were sacrificed at 24 weeks after initiation of experiment and then examined with the incidence and multiplicities of colorectal polyps. The incidence of colorectal tumors were significantly reduced in iNOS gene knockout mice (22.9%), compared to that of control mice (61.4%). The multiplicity in colorectal polyps in the iNOS knockout mice were 0.37±0.77 (n = 35), being significantly less than wild type mice (1.02 ± 1.15, n = 44). The sizes of the polyps in the iNOS gene knockout mice were also decreased. However, according to histopathological observations, most of the adenocarcinomas from iNOS knockout mice were less differentiated compared to those of wild type mice. From the results, iNOS-mediated NO might have a promotive potential in the early stage, but a suppressive effect in the late stage of colorectal carcinogenesis.
목차
Materials and Methods
Results
Discussion
Acknowledgment
References
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UCI(KEPA) : I410-ECN-0101-2009-510-016362909