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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.3
- 수록면
- 97 - 103 (7page)
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Banha (Pinellia ternata) is a herbal medicine which is composed of alkaloid substances, homegentisic acid, 3,4-dihydroxybenzaldehyde and 3,4-diglycosilic benzaldehyde and is mainly prescribed in cough with dyspnea, gastric retention, distention and pain of the thorax and abdomen, lymph node tuberculosis, carbuncle, and furuncle. The use of raw Banha has been prohibited in pregnant woman because of it's strong toxicity. In this study, to investigate whether Banha affects the antioxidant system of male reproductive organs, we analyzed the mRNA expression patterns of glutathione peroxidase (GPx) family (type 1-4) in the reproductive organs of rats exposed to Banha. Banha extracts (0.05, 0.1, 0.2, 0.5, 1, and 2 g/㎏ body weight) were treated to 6 week-old rats for 4 weeks per oral. Total RNAs were extracted from testis, epididymis, prostate, and seminal vesicle and then RT-PCR was perfomed with the specific primers of each GPx enzyme. In epididymis and prostate, GPx1 mRNA were decreased by Banha treatment except for 2 g/㎏ treatment in prostate. However, GPx1 mRNA in seminal vesicle was increased by Banha treatment. GPx2 mRNA was increased in testis and seminal vesicle. GPx4 (PHGPx) mRNA was decreased in seminal vesicles by 0.1 and 1 g/㎏ treatment of Banha. These findings indicate that Banha may affect the antioxidant system of male reproductive organs, although further study is necessary.
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