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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 357 - 366 (10page)
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초록· 키워드
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To investigate the possible enhancement of genotoxicity in stress environment, we examined the effect of genotoxic material in oxidative stress-induced condition using human cell line. Human lymphoblast cell line, TK6 was treated with hydrogen peroxide (H₂O₂) for induction of oxidative stress, and treated with N’-methyl-N’-nitroguanidine (MNNG), as a genetoxic material. We carried out MTS assay to set treatment doses. TK6 was treated with H₂O₂ as 6.75 (low dose) or 13.5 μM (high dose) for 2 h, and treated with MNNG as 0.117 (low dose), 0.234 (middle dose), 0.468 μM (high dose) for 2 h. As results, a treatment of MNNG induced DNA damage as dose dependently. And TK6 treated with H₂O₂ at low as well as high dose followed by MNNG treatment showed higher DNA damage compared to MNNG alone treated groups. Malondialdehyde, as a marker of lipid peroxidation was increased in H₂O₂ and MNNG treated groups. Real-time RT-PCR analyses for expression sion of several antioxidative enzymes showed that catalase mRNA and glutathione peroxidase 1 mRNA expression were decreased in H₂O₂ and MNNG treated groups. Taken together, we conclude that genotoxicity induced by MNNG is enhanced in a condition of oxidative stress induced by H₂O₂ and it suggests that it should be associated with induction of lipid peroxidation and decrease of antioxidant enzymes.
목차
ABSTRACT
서론
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Alija AJ / 2005 / Cyto-and genotoxic potential of beta-carotene and cleavage products under oxidative stress : 159 ~ 163
2. [학술지(정기간행물)] - Alija AJ / 2006 / Beta-carotene breakdown products enhance genotoxic effects of oxidative stress in primary rat hepatocytes 27 : 1128 ~ 1133
3. [학술지(정기간행물)] - Alija AJ / 2004 / Cytotoxic and genotoxic effects of beta-carotene breakdown products on primary rat hepatocytes, Car- 25 : 827 ~ 831
4. [학술지(정기간행물)] - Elchuri S / 2005 / CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life 24 : 367 ~ 380
5. [학술지(정기간행물)] - Fukushima S / 1999 / Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: relevance to risk assessment 143 : 157 ~ 159
2. [학술지(정기간행물)] - Alija AJ / 2006 / Beta-carotene breakdown products enhance genotoxic effects of oxidative stress in primary rat hepatocytes 27 : 1128 ~ 1133
3. [학술지(정기간행물)] - Alija AJ / 2004 / Cytotoxic and genotoxic effects of beta-carotene breakdown products on primary rat hepatocytes, Car- 25 : 827 ~ 831
4. [학술지(정기간행물)] - Elchuri S / 2005 / CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life 24 : 367 ~ 380
5. [학술지(정기간행물)] - Fukushima S / 1999 / Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: relevance to risk assessment 143 : 157 ~ 159
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UCI(KEPA) : I410-ECN-0101-2009-539-016342113