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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 447 - 452 (6page)
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초록· 키워드
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Green tea, a beverage commonly consumed in Asian countries, is a significant source of a type of flavonoids called catechins. Epigallocatechin-3-gallate (EGCG) is the most abundant chemical components of these catechins. It has been reported that glomerulosclerosis mediated by the dysfunction of mesangial cells and insulin-like growth factors (IGFs) are associated with the development of diabetic nephropathy. Hyperglycemia is a major factor to develop the onset of diabetic nephropathy. Thus, we examined the effect of EGCG on high glucose-induced dysfunction of primary cultured rat mesangial cells. In the present study, treatment of 25 mM glucose increased IGF-Ⅰ and IGF-Ⅱ secretion in mesangial cells. Supplementation of EGCG (＞1 ㎍/㎖) resulted in the prevention of high glucose-induced increase of IGF-Ⅰ and IGF-Ⅱ secretion in mesangial cells. In addition, treatment of EGCG reduced the formation of lipid peroxide and GSH contents. EGCG also ameliorates high glucose-induced increase of arachidonic acid release and decrease of prostaglandin E₂. In conclusion, EGCG prevented high glucose-induced dysfunction of mesangial cells via inhibition of oxidative stress and arachidonic acid pathways.
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재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (36)
참고문헌 신청
1. [학술지(정기간행물)] - Agardh, C.D / 2002 / Effects of inhibition of glycation and oxidative stress on the development of diabetic nephropathy in rats 16 : 395 ~ 400
2. [학술지(정기간행물)] - Anderson M / 1989 / Determination of glutathione and glutathione disulfide in biological samples : 548 ~ 554
3. [학술지(정기간행물)] - Bowsher / 1991 / Measurement of insulin-like growth factor-II in physiological fluids and tissues An improved extraction procedure and radioimmunoassay for human and rat fluids endocri (logy 128) : 805 ~ 814
4. [학술지(정기간행물)] - Bradford / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding : 248 ~ 254
5. [학술지(정기간행물)] - Brown, M.D / 1999 / Green tea (Camellia sinensis) extract and its possible role in the prevention of cancer 4 : 360 ~ 370
2. [학술지(정기간행물)] - Anderson M / 1989 / Determination of glutathione and glutathione disulfide in biological samples : 548 ~ 554
3. [학술지(정기간행물)] - Bowsher / 1991 / Measurement of insulin-like growth factor-II in physiological fluids and tissues An improved extraction procedure and radioimmunoassay for human and rat fluids endocri (logy 128) : 805 ~ 814
4. [학술지(정기간행물)] - Bradford / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding : 248 ~ 254
5. [학술지(정기간행물)] - Brown, M.D / 1999 / Green tea (Camellia sinensis) extract and its possible role in the prevention of cancer 4 : 360 ~ 370
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The Regulation of Insulin-Like Growth (IGF) Factors and IGF Binding Proteins by High Glucose in Mesangial Cells
대한의생명과학회지
2004 .09
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Epigallocatechin Gallate, a Constituent of Green Tea, Regulates High Glucose-induced Apoptosis
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
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타이타늄 표면에 코팅된 epigallocatechin gallate의 사람치수세포 분화 촉진
대한치과재료학회지
2015 .09
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Activity of Green Tea Polyphenol Epigallocatechin-3-gallate Against Ovarian Carcinoma Cell Lines
Cancer Research and Treatment
2004 .01
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Role of Advanced Glycation End Products in TGF-β1 and Fibronectin Expression in Mesangial Cells Cultured under High Glucose
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2005 .01
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Anti-apoptotic Effect of Bojungbangam-tang Ethanol Extract on Cisplatin-Induced Apoptosis in Rat Mesangial Cells
동의생리병리학회지
2006 .01
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난소암 세포주에서 녹차 추출물의 항암 작용
Obstetrics & Gynecology Science
2004 .01
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(-)-Epigallocatechin-3-Gallate Induces Apoptosis and Inhibits Invasion and Migration of Human Cervical Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2012 .01
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Epigallocatechin Gallate Prevents Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin in Mice
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
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Hepatocyte에서 고포도당에 의한 IGFs 분비와 PKC 및 산화성 스트레스와의 관련성에 관한 연구
Laboratory Animal Research
2004 .12
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Protective Effect of EGCG Against Reactive Oxygen Species-induced Stress
International Journal of Oral Biology
2005 .01
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Hepatocyte에서 고포도당에 의한 IGFs 분비와 PKC 및 산화성 스트레스와의 관련성에 관한 연구
한국실험동물학회 학술발표대회 논문집
2005 .06
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Epigallocatechin-3-gallate Regulates Inducible Nitric Oxide Synthase Expression in Human Umbilical Vein Endothelial Cells
Laboratory Animal Research
2011 .06
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Comparative Analysis of Agricultural Products Cultured in Conventional and Pesticide-Free Condition:
Laboratory Animal Research
2008 .06
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Effect of Heat-epimerized-catechin-mixture Rich in Gallocatechin-3-gallate on Skin Barrier Recovery
대한화장품학회지
2008 .01
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마우스세포주 Balb/c 3T3 A31-1-1에서 Epigallocatechin gallate(EGCG)의 세포암화 억제효과에 대한 유전자발현 해석
한국환경성돌연변이·발암원학회지
2006 .12
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Epigallocatechine gallate에 의한 amyloid β peptide 유도성 신경세포독성의 억제
해부·생물인류학
2005 .06
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Epigallocatechin-3-gallate protects against beta-amyloid-induced memory impairment and oxidative stress
한국실험동물학회 학술발표대회 논문집
2008 .05
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UCI(KEPA) : I410-ECN-0101-2009-510-016250039