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자료유형
학술저널
저자정보
저널정보
한국독성학회 Toxicological Research Journal of Toxicology and Public Health Vol.22 No.4
발행연도
2006.12
수록면
365 - 373 (9page)

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The present study was designed to characterize the effects of estrogen receptor agonist (4,4',4"-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol, PPT) on liver and kidney in male mouse using a light microscopic analysis. PPT was subcutaneously given to adult male mice at a weekly dosage of 178.6 ㎎/㎏ in a volume 0.08 ㎖ of vehicle for 3, 5 and 8 weeks. There were differences in body and organ weights between control and the treated groups. Body and kidney weights were decreased in treated group whereas, liver weight was increased. In microscopic observations, sinusoidal diameter in liver of treated group was increased 156%, 216% and 255% on week 3, 5 and 8 respectively. Compared to the control, diameter of proximal convoluted tubules in kidney was increased 37% and 43% on week 5 and 8 in treated group. Whereas, height of epithelial cells in the proximal tubules was reduced at all time points. These results suggest that microstructure of liver and kidney was changed by treatment of estrogen receptor agonist PPT in the male mice.

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