지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 54 - 63 (10page)
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초록· 키워드
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To investigate the toxic effects of cheonggukjang (CKJ) manufactured using mixed cultures of Bacillus subtilis MC31 and Lactobacillus sakei 383 on the liver and kidney of ICR mice, an alteration on the related markers including body weight, organ weight, urine composition, liver pathology and kidney pathology were analyzed after oral administration at dosage of 25, 50 and 100 mg/kg body weight/day of CKJ for 14 days. Any significant toxicity was not observed on the body and organ weight, clinical phenotypes, urine parameters and mortality in the CKJ-treated group compared with the vehicle-treated group. Also, liver toxicity analysis revealed no significant increase in alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) or lactate dehydrogenase (LDH) in response to CKJ. Additionally, the specific pathological features induced by most toxic compounds were not observed upon liver histological analysis. Furthermore, kidney toxicological analysis revealed that blood urea nitrogen (BUN) and the serum creatinine (Cr) levels and pathological features on histological sections did not differ significantly between the vehicle- and CKJ-treated groups. Overall, these results suggest that CKJ does not induce any specific toxicity in liver and kidney organs of ICR at dose of 100 mg/kg body weight/day as no observed adverse effect level (NOAEL).
목차
Materials and Methods
Results
Discussion
References
참고문헌 (41)
참고문헌 신청
1. [학술지(정기간행물)] - Lee JJ. / 1999 / Fermentation patterns of chungkookjang and Kanjang by Bacillus licheniformis B1 / J Microbiol 35 (4) : 296 ~ 301
2. [학술지(정기간행물)] - Su CL. / 2007 / Supernatant of bacterial fermented soybean induces apoptosis of human hepatocellular carcinoma Hep 3B cells via activation of caspase 8 and mitochondria / Food Chem Toxicol 45 (2) : 303 ~ 314
3. [학술지(정기간행물)] - Nakajima N. / 2005 / Analysis of isoflavone content in tempeh, a fermented soybean, and preparation of a new isoflavone-enriched tempeh / J Biosci Bioeng 100 (6) : 685 ~ 687
4. [학술지(정기간행물)] - Kwon DY. / 2006 / The isoflavonoid aglycone-rich fractions of Chungkookjang, fermented unsalted soybeans, enhance insulin signaling and peroxisome proliferator-activated receptor-gamma activity in vitro / Biofactors 26 (4) : 245 ~ 258
5. [학술지(정기간행물)] - Lee SJ. / 2013 / Immunostimulatory activity of polysaccharides from Cheonggukjang / FOOD AND CHEMICAL TOXICOLOGY 59 : 476 ~ 484
2. [학술지(정기간행물)] - Su CL. / 2007 / Supernatant of bacterial fermented soybean induces apoptosis of human hepatocellular carcinoma Hep 3B cells via activation of caspase 8 and mitochondria / Food Chem Toxicol 45 (2) : 303 ~ 314
3. [학술지(정기간행물)] - Nakajima N. / 2005 / Analysis of isoflavone content in tempeh, a fermented soybean, and preparation of a new isoflavone-enriched tempeh / J Biosci Bioeng 100 (6) : 685 ~ 687
4. [학술지(정기간행물)] - Kwon DY. / 2006 / The isoflavonoid aglycone-rich fractions of Chungkookjang, fermented unsalted soybeans, enhance insulin signaling and peroxisome proliferator-activated receptor-gamma activity in vitro / Biofactors 26 (4) : 245 ~ 258
5. [학술지(정기간행물)] - Lee SJ. / 2013 / Immunostimulatory activity of polysaccharides from Cheonggukjang / FOOD AND CHEMICAL TOXICOLOGY 59 : 476 ~ 484
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UCI(KEPA) : I410-ECN-0101-2015-500-001679194