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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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The uptake of cadmium in animals is mainly accumulated in and affected to the liver and kidney by binding with red blood cells and serum albumin. The process accounts for more than 50% of the total accumulated cadmium in the body. The kidneys may be damaged without regarding the pathway uptake of cadmium. In a group of rats on supplements of 1% chlorella and 40 ppm cadmium, the concentration of cadmium in urine greatly decreased by 66% compared to control group, and the total synthesis of metallothionein decreased by 48.6% compared to control group. However, no previous study has assessed the protective effect on kidney damage induced by cadmium uptake through supplementation with chlorella. This study analyzed the biochemical marker for kidney damage in the rats after uptake of 40 ppm CdCl<sub>2</sub> and supplementation of the diet of Sprague Dawley (SD) rats with 1%, 5%, and 10% chlorella during 4 weeks. In a group of SD rats on supplementation with 1% chlorella and uptake of 40 ppm CdCl<sub>2</sub>, β<sub>2</sub> microglobulin in the urine was found to be 3.1±0.6 μg/L, a decrease of 58% compared to a group of SD rats on uptake of CdCl<sub>2</sub> only, in which the β<sub>2</sub> microglobulin was found to be 4.9±0.7 μg/L. According to the results of histopathological observation, the accumulation of mild and localized chronic inflammatory cells in kidney tissues was observed in 50% of the SD rats on uptake of cadmium only. In contrast, only 30% of the SD rats on supplementation with 1% chlorella and uptake of 40 ppm CdCl<sub>2</sub>, representing a histopathological abnormality, and there were no histopathological abnormalities at all in groups of SD rats on supplementation with 5% or 10% chlorella and uptake of 40 ppm CdCl<sub>2</sub>. In conclusion, protein, calcium, and iron, which account for more than 50% of the total dried chlorella composition, may contribute to the reduction nephrotoxicity by stimulating both inhibited absorption of cadmium and increased excretion of accumulated cadmium in kidneys.
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재료 및 방법
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고찰
REFERENCES
참고문헌 (16)
참고문헌 신청
[학술지(정기간행물)] - E,Aughey / 1984 / Histopathology of early effects of oral cadmium in the rat kidney / Environ Health Perspectives 54 : 153 ~ 161
[학술지(정기간행물)] - A,Bernard / 1981 / Characterigation of the proteinuria induced by prolonged oral of cadmium in female rats / Toxicology 20 : 345 ~ 357
[학술지(정기간행물)] - MG,Cherian / 1976 / Cadmium-metallothionein-induced nephropathy / Toxicol Appl pharmacol. 38 : 399 ~ 408
[단행본] - L,Friberg / 1985 / Cadmium and health: A Toxicology and Epidemiological Appraisal Vol I : 162 ~ 163
[단행본] - RA,Goyer / 1984 / Correlation for parameters of cadmium exposure with onset of cadmium-induced nephropathy in rats / J Environ Pathol Toxicol Oncol. 5 : 89 ~ 100
[학술지(정기간행물)] - A,Bernard / 1981 / Characterigation of the proteinuria induced by prolonged oral of cadmium in female rats / Toxicology 20 : 345 ~ 357
[학술지(정기간행물)] - MG,Cherian / 1976 / Cadmium-metallothionein-induced nephropathy / Toxicol Appl pharmacol. 38 : 399 ~ 408
[단행본] - L,Friberg / 1985 / Cadmium and health: A Toxicology and Epidemiological Appraisal Vol I : 162 ~ 163
[단행본] - RA,Goyer / 1984 / Correlation for parameters of cadmium exposure with onset of cadmium-induced nephropathy in rats / J Environ Pathol Toxicol Oncol. 5 : 89 ~ 100
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UCI(KEPA) : I410-ECN-0101-2009-510-017357035