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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The rate of metallothionein synthesis on cadmium-poisoned rats reflects the level of toxicity, and also it reduces the toxicity which is caused by the uptake of cadmium. Chlorella supplementation in the diets of the cadmium-poisoned rats decreased the concentration of cadmium in blood and urine compared with the control group. Although the liver and kidneys of rats are major target organs of cadmium and coherence of metallothionein and cadmium, no previous study has determined the correlation between the rate of metallothionein synthesis in the liver and kidneys of rats and dietary supplementation of chlorella with cadmium uptake. This study analyzed total metallothionein level on the tissue of the liver and kidneys, the concentration of cadmium bound to the metallothionein, and the total concentration of cadmium on the tissue of the liver and kidneys after dietary supplementation with 1%, 5%, and 10% dried chlorella and 40 ppm of cadmium to 46 male SD rats (mean weight: 150±20 g) for 4 weeks. According to the data analysis of the total rate of metallothionein synthesis in the liver and kidneys, the group of SD rats on the supplementation with 1 % chlorella and 40 ppm of cadmium showed a rate of 93.2±8.9 ng/g, a significant decrease of 58.8% compared to that of the control group of SD rats on the supplementation with cadmium only, which showed a rate of 227.3 ±32.5 ng/g (P=0.0001). In contrast, no significant difference was observed through the changing of chlorella concentrations between 5% and 10% chlorella supplementation with cadmium. The group supplemented with 1% or greater chlorella levels represented greater decrease in the total cadmium concentration of the kidney and liver tissues, the amount of total metallothionein synthesis, the amount of metallothionein with binding to cadmium, and the concentration of free cadmium without binding to metallothionein. Consequently, the supplementation of 1% and 5% chlorella was effective in reducing the synthesis of metallothionein for cadmium uptake, but increased the rate of binding of cadmium to metallothionein.
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재료 및 방법
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고찰
REFERENCES
참고문헌 (11)
참고문헌 신청
[단행본] - Bernard, A / 1986 / Cadmium: Handbook of experimental pharmacology. / Springer. Berlin,Germany : 303 ~ 374
[학술지(정기간행물)] - Cantilena LR, JR / 1980 / Comparison of the effectiveness of several Chelators after single administration on the toxicity, excretion, and distribution of cadmium / Toxicol Appl Pharmacol. 53 : 510 ~ 514
[학술지(정기간행물)] - E,Casalino / 2002 / Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium / Toxicology 179 : 37 ~ 50
[학술지(정기간행물)] - PT,Goering / 1984 / Tolerance to cadmium-induced hepatotoxicity following cadmium pretreatment / Toxicol Appl pharmacol. 74 : 308 ~ 313
[학술지(정기간행물)] - RA,Goyer / 1989 / Non-metallothioneinbound cadmium in the pathogenesis of cadmium nephrotoxicity in the rat / Toxicol Appl Pharmacol 101 : 232 ~ 244
[학술지(정기간행물)] - Cantilena LR, JR / 1980 / Comparison of the effectiveness of several Chelators after single administration on the toxicity, excretion, and distribution of cadmium / Toxicol Appl Pharmacol. 53 : 510 ~ 514
[학술지(정기간행물)] - E,Casalino / 2002 / Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium / Toxicology 179 : 37 ~ 50
[학술지(정기간행물)] - PT,Goering / 1984 / Tolerance to cadmium-induced hepatotoxicity following cadmium pretreatment / Toxicol Appl pharmacol. 74 : 308 ~ 313
[학술지(정기간행물)] - RA,Goyer / 1989 / Non-metallothioneinbound cadmium in the pathogenesis of cadmium nephrotoxicity in the rat / Toxicol Appl Pharmacol 101 : 232 ~ 244
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UCI(KEPA) : I410-ECN-0101-2009-510-017357020