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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.9
- 수록면
- 375 - 382 (8page)
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초록· 키워드
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This study aimed to investigate whether nociceptin is implicated in the trigeminovascular responses to electrical stimulation of trigeminal ganglion in rats. An open cranial window was prepared on the right parietal bone of male Sprague-Dawley rats. Trigeminovascular system was stimulated by electrical stimulation of trigeminal ganglion (ETS ; 5 ms,5 Hz, 3 V). Neonatal capsaicin treatment was performed with subcutaneous administration of capsaicin (50mg/mg) within the first 24 hours after birth. Changes in regional cerebral blood flow were continuously measured through the cranial window by laser-Doppler flowmetry, and the expression of nociceptin-like immunoreactivity was determined by immunohistochemistry. ETS caused increases in regional blood flow of pial arteriole in a voltage-dependent manner, ETS markedly and voltage-dependently increased the expression of nociceptin-like immunoreactivity in dura mater ipsilateral rather than contralateral to ETS. The nociceptin-like immunoreactivity was markedly reduced by pretreatments with calcitonin gene-related peptide(8-37) (CGRP<sub>8-37</sub>, a CGRP<sub>1</sub>, receptor antagonist), L-733060 (a NK<sub>1</sub> receptor antagonist), and [Nphe<sup>1</sup>]nociceptin(1-13)NH<sub>2</sub> (a selective and competitive nociceptin receptor antagonist) as well as by neonatal capsaicin treatment. These results suggest that the electrical stimulation of trigeminal ganglion causes prominent expression of nociceptin within dura mater, in which not only neuropeptides inclucing substance P and CGRP but also nociceptin are implicated in the trigeminovascular responses to electrical trigeminal ganglion stimulation.
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영어초록
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재료 및 방법
결과
고찰
REFERENCES
참고문헌 (38)
참고문헌 신청
[학술지(정기간행물)] - KH,Andres / 1987 / Nerve fibres and their terminals of the dura mater encephali of the rat / Anat Embryol (Berl) 175 : 289 ~ 301
[학술지(정기간행물)] - B,Anton / 1996 / Immunohistochemical localization of ORL-1 in the central nervous system of the rat / J Comp Neurol. 368 : 229 ~ 251
[학술지(정기간행물)] - T,Bartsch / 2002 / The ORL-1 (NOP1) receptor ligand nociceptin/orphanin FQ (N/OFQ) inhibits neurogenic dural vasodilatation in the rat / Neuropharmacology 43 : 991 ~ 998
[학술지(정기간행물)] - G,Calo' / 2000 / Pharmacology of nociceptin and its receptor: a novel therapeutic target / Br J Pharmacol. 129 : 1261 ~ 1283
[학술지(정기간행물)] - L,Edvinsson / 2001 / Sensory nerves in man and their role in primary headaches / Cephalalgia 21 : 761 ~ 764
[학술지(정기간행물)] - B,Anton / 1996 / Immunohistochemical localization of ORL-1 in the central nervous system of the rat / J Comp Neurol. 368 : 229 ~ 251
[학술지(정기간행물)] - T,Bartsch / 2002 / The ORL-1 (NOP1) receptor ligand nociceptin/orphanin FQ (N/OFQ) inhibits neurogenic dural vasodilatation in the rat / Neuropharmacology 43 : 991 ~ 998
[학술지(정기간행물)] - G,Calo' / 2000 / Pharmacology of nociceptin and its receptor: a novel therapeutic target / Br J Pharmacol. 129 : 1261 ~ 1283
[학술지(정기간행물)] - L,Edvinsson / 2001 / Sensory nerves in man and their role in primary headaches / Cephalalgia 21 : 761 ~ 764
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UCI(KEPA) : I410-ECN-0101-2009-510-017356725