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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The present study was conducted to determine whether local production of neutrophil chemoattractant cytokines preceded the influx of neutrophils following dermal scald burn injury. In order to inhibit the influx of neutrophils, we induced scald burn injury on dorsal skin of rats (TBSA 15%) and spread Rhubarb (R. undulatum L.) and complex (Rhubarb+Olibanum+Myrrha) on scald skin in rats.
1. Levels of dermal KC, the indicator of skin inflammation, caused by burn gradually increased 5 hours, 24 hours (p＜0.001) and 72 hours (p＜0.001) after the burn occurred. After 24 hours it occurs, KC in skin was decreased by both skin spread of Rhubarb (p＜0.05) and complex (p＜0.05) compared to scald burn group. After 72 hours, KC by skin spread of Rhubarb and complex was significantly decreased (p＜0.01), and the inhibition effect of KC production by complex is higher than by Rhubarb.
2. KC content in serum was increased (p＜0.01) at 24 hours after burn injury and comes down back to the normal level after 72 hours. At 24 hours postburn, both Rhubarb (p＜0.05) and complex (p＜0.01) skin spread decreased KC in serum. The inhibition effect of KC production by complex skin spread group is higher than by Rhubarb skin spread group.
The data suggest that the KC production effects by Rhubarb skin spread group and complex skin spread group are high. Especially the endurance of the effect by complex skin spread group was longer than by Rhubarb skin spread group. The inhibition effect of KC production by complex skin spread group increases more than by Rhubarb skin spread group as time passes.
1. Levels of dermal KC, the indicator of skin inflammation, caused by burn gradually increased 5 hours, 24 hours (p＜0.001) and 72 hours (p＜0.001) after the burn occurred. After 24 hours it occurs, KC in skin was decreased by both skin spread of Rhubarb (p＜0.05) and complex (p＜0.05) compared to scald burn group. After 72 hours, KC by skin spread of Rhubarb and complex was significantly decreased (p＜0.01), and the inhibition effect of KC production by complex is higher than by Rhubarb.
2. KC content in serum was increased (p＜0.01) at 24 hours after burn injury and comes down back to the normal level after 72 hours. At 24 hours postburn, both Rhubarb (p＜0.05) and complex (p＜0.01) skin spread decreased KC in serum. The inhibition effect of KC production by complex skin spread group is higher than by Rhubarb skin spread group.
The data suggest that the KC production effects by Rhubarb skin spread group and complex skin spread group are high. Especially the endurance of the effect by complex skin spread group was longer than by Rhubarb skin spread group. The inhibition effect of KC production by complex skin spread group increases more than by Rhubarb skin spread group as time passes.
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