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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.6
- 수록면
- 105 - 111 (7page)
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Objectives : Neuropeptide Y(NPY) consists of 36 amino acid and is one of the most abundant peptides found in the mammalian brain. The distribution of binding sites for NPY in CNS is consistent with the possibility that NPY can modulate cognitive process. Mounting evidence suggests that ethanol exerts effects on learning and memory by altering cellular activity in the hippocampus and related structures. The present study was designed to investigate the effects of ethanol on the expression of NPY in the hippocampus of the rat brain.
Methods : Adult male Spraque-Dawley rats were used. They were assigned to ethanol exposure group(N=8) and normal control without ethanol exposure(N=8). After 8 weeks of ethanol exposure, immunohistochemical analysis was performed. We compared the NPY expression in the hippocampus between two groups.
Results : 1) In the ethanol exposure group, the number of NPY-positive cells was significantly decreased in the dentate gyrus and CA1 region of hippocampus compared with normal control. 2) There was no significant difference in the number of NPY-positive cells in CA3 region between two groups.
Conclusion : This study demonstrates that the presence of significant neuronal damage in the hippocampus after long-term ethanol exposure. Furthermore, theses findings suggest that dentate gyrus and CA1 region may be more susceptible than CA3 region to ethanol-induced neuronal damage. Our results support the possible mechanisms involved in the role of NPY in ethanol-induced memory deficit.
Methods : Adult male Spraque-Dawley rats were used. They were assigned to ethanol exposure group(N=8) and normal control without ethanol exposure(N=8). After 8 weeks of ethanol exposure, immunohistochemical analysis was performed. We compared the NPY expression in the hippocampus between two groups.
Results : 1) In the ethanol exposure group, the number of NPY-positive cells was significantly decreased in the dentate gyrus and CA1 region of hippocampus compared with normal control. 2) There was no significant difference in the number of NPY-positive cells in CA3 region between two groups.
Conclusion : This study demonstrates that the presence of significant neuronal damage in the hippocampus after long-term ethanol exposure. Furthermore, theses findings suggest that dentate gyrus and CA1 region may be more susceptible than CA3 region to ethanol-induced neuronal damage. Our results support the possible mechanisms involved in the role of NPY in ethanol-induced memory deficit.
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UCI(KEPA) : I410-ECN-0101-2009-513-017218965