지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1995.12
- 수록면
- 174 - 180 (7page)
이용수
초록· 키워드
오류제보하기
Depression is one of the most common of the major psychiatric disorders, with a high life time prevalence. It is known that, although different antidepressants have different putative mechanisms of action, the distinctions between them in terms of efficacy are extremely small. At present no antidepressant has shown efficacy greater than that of the first-generation compounds, the tricyclic antidepressants(TCAs) and the monoamine oxidase inhibitors. When selecting an antidepressant, several factors such as safety, tolerability, efficacy, cost effectiveness, and simplicity must be considered. Unfortunately, the tricyclic antidepressants have other effects that are not related to their therapeutic activity, including muscarinic, histaminergic, alpha-1-adrenergic blockade. And these actions cause dry mouth, constipation, urinary retention, sedation, orthostatic hypotension, cardiac toxicity and weight gain. Other antidepressants affecting only the serotonin reuptake site have been developed and termed as selective serotonin reuptake inhibitors(SSRis). Several potential benefits may anse from these drugs in the aspects with side effect and tolerability. At present exciting changes are taking place in our uriderstanding of the neurobiology of depression and its treatment.
The goal today is development of drugs With affinity for specific sites in the brain that mediate antidepressant activity but without affinity for sites involved in other types of pharmacologic effects. The newest class of antidepressant is the serotonin-noradrenergic reuptake inhibitos(SNRis). These include venlafaxine, duloxeting and milnacipran. Several classes of serotonergic drugs are in development. The 5-HT2 antagonists/5-HT reuptake inhibitors such as nefazodone and mirtazepine have shown evidence of antidepressant activity and possess a good overall tolerability profile. These new-generation antidepressant are expected to offer the potential for efficacy in a broad range of patients, rapid onset of action, and a safety/tolerability profile similar to SSRIs and superior to the TCAs.
The goal today is development of drugs With affinity for specific sites in the brain that mediate antidepressant activity but without affinity for sites involved in other types of pharmacologic effects. The newest class of antidepressant is the serotonin-noradrenergic reuptake inhibitos(SNRis). These include venlafaxine, duloxeting and milnacipran. Several classes of serotonergic drugs are in development. The 5-HT2 antagonists/5-HT reuptake inhibitors such as nefazodone and mirtazepine have shown evidence of antidepressant activity and possess a good overall tolerability profile. These new-generation antidepressant are expected to offer the potential for efficacy in a broad range of patients, rapid onset of action, and a safety/tolerability profile similar to SSRIs and superior to the TCAs.
목차
영어 초록
서론
삼환계 항우울제와 우울증의 신경생물학적 소견
선택적 세로토닌 재흡수 억제제(SSRls)들
삼환계 항우울제들과 SSRl들과의 임상적 비교
새로운 항우울제들
결어
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UCI(KEPA) : I410-ECN-0101-2009-513-017199038