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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2002.12
- 수록면
- 13 - 19 (7page)
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초록· 키워드
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To elucidate the regulatory mechanism for expression of sialylglycoconjugates and their biological functions, ninetheen sialyltransferase cDNAs including eleven by our group or co-works have been cloned and characterized so far. The cloned sialyltransferases are classified into four families according to the carbohydrate linkages they synthesize: α2,3-sialyltransferase (ST3Gal Ⅰ-Ⅵ), α2,6-sialyltransferase (ST6Gal Ⅰ), GalNAc α2,6-sialyltransferase (ST6GalNAc Ⅰ-Ⅵ), and α2,8-sialyltransferase (ST8Sia Ⅰ-Ⅵ). Each of the sialyltransferase genes is differentially expressed in a tissue-, cell type-, and stage-specific manner. These enzymes differ in their substrate specificity and various biochemical parameters. However, enzymatic analysis conducted in vitro with recombinant enzyme revealed that one linkage can be synthesized by multiple enzymes. We present here an overview of structure and function of sialyltransferases performed by our group and co-works. Genomic structures and transcriptional regulation of two kinds of human sialyltransferase gene are also presented.
목차
Abstract
1. Introduction
2. The cloned mammalian sialyltransfereases and their substrate specificity
3. Structure of sialyltransfereases
4. References
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UCI(KEPA) : I410-ECN-0101-2009-470-015437740