지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 261 - 268 (8page)
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Differences in host ethnicities and geographical distributions may influence the genetic variation and pathogenesis of Helicobacter pylori strains, particularly with respect to those with a high risk of gastric cancer and in Asian Enigma regions. We simultaneously identified H. pylori virulence-associated genes involved in inflammation and cell damage in Thai and Korean dyspeptic patients. The virulence-associated gene cagA, cagA genotypes (East Asian and Western type cagA), vacA genotypes (s- and m-), oipA, and sabA were detected in Thai and Korean dyspeptic patients by polymerase chain reaction (PCR), real-time PCR, and DNA sequence analysis. Comparisons between the two regions showed that cagA, East Asian type cagA, and vacA s1/m1 in Korean dyspeptic patients occurred at rates of 100%, 86.67%, and 88.89%, respectively (p < 0.05). The oipA- and sabA-positive samples were significantly more predominant in the Korean population (95.56%, 91.11%) than in the Thai population (32%, 34%). DNA sequence analysis revealed differences in the patterns of cytosine-thymine dinucleotide repeats of oipA and sabA among the two populations of dyspeptic patients. Our results indicate that the H. pylori strains detected in the two regions were divergent, and strains colonizing the Korean dyspeptic patients may be more virulent than those in the Thai population. Our data may help explain H. pylori pathogenesis in Asian Enigma areas with a low gastric cancer incidence. However, other factors involving H. pylori infection in these two regions should be further analyzed.
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등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
Peek RM Jr. / 2002 / Helicobacter pylori and gastrointestinal tract adenocarcinomas / Nat. Rev. Cancer. 2:28~37
International Agency for Research on Cancer (IARC) / 1994 / Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994 / IARC Monogr Eval Carcinog Risks Hum 61:1~241
Miwa H / 2002 / H. pylori and gastric cancer: the Asian enigma / Am. J. Gastroenterol. 97:1106~1112
Uchida T / 2015 / Helicobacter pylori infection in Thailand: A nationwide study of the CagA phenotype / PLoS One 10:e0136775
Eusebi LH / 2014 / Epidemiology of Helicobacter pylori infection / Helicobacter 19:1~5
International Agency for Research on Cancer (IARC) / 1994 / Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994 / IARC Monogr Eval Carcinog Risks Hum 61:1~241
Miwa H / 2002 / H. pylori and gastric cancer: the Asian enigma / Am. J. Gastroenterol. 97:1106~1112
Uchida T / 2015 / Helicobacter pylori infection in Thailand: A nationwide study of the CagA phenotype / PLoS One 10:e0136775
Eusebi LH / 2014 / Epidemiology of Helicobacter pylori infection / Helicobacter 19:1~5
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