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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.6
- 수록면
- 264 - 270 (7page)
이용수
초록· 키워드
오류제보하기
This study was performed to evaluate the effect of red-yeast-rice on blood lipids and also to investigated the relation of blood lipids, bone related hormones, and bone mineral density in overiectomized rats. Forty female rats (body weight 210±5g) were divided into two groups. The rats in the first group were ovariectomized which the others received sham operation (SHAM). And then each rat group was further divided into control diet (casein 20%) and red-yeast-rice powder supplemented (0.1%) diet group. All rats were fed on experimental diet and deionized water ad libitum for 9 weeks. Bone mineral density (BMD) and bone mineral content (BMC) were measured using PIXImus in spine and femur. Bone formation and bone resorption were measured by serum osteocalcin and urinary deoxypyridinoline (DPD) crosslinks value. Serum growth hormone, IGF-1 and calcitonin were analyzed using radioimmunoassay kits. The red-yeast-rice group had significantly lower the blood triglyceride concentration and had lower the blood total cholesterol concentration than casein group did in ovariectomized rats. And the red-yeast-rice group than casein group in ovariectomized rats. The red-yeast-rice group had significantly lower the atherogenic index than control group within the ovariectomized groups. In the experimental rats, serum total cholesterol concentration was negatively correlated with femur BMC and crosslink value. Crosslink value was negatively correlated with spine BMC and IGF-1. Osteocalcin concentration was negatively correlated with crosslink value. Growth hormone was negatively correlated with crosslink value and positively correlated with spine BMC. The findings of this study suggest that red-yeast-rices are beneficial for blood lipid in ovariectomized rats. And when considering a population-based public health approach to lowering cholesterol and bone loss, and preventing coronary heart disease and osteoporosis, the red-yeast-rice dietary supplement could provide a new approach for the maintenance of healthier cholesterol and bone.
목차
Abstract
서론
연구내용 및 방법
결과 및 고찰
요약 및 결론
감사의 글
문헌
참고문헌 (24)
참고문헌 신청
Arjmandi AH, Getlinger MJ, Goyal NV, Alekel L, Hasler CL, Juma S, Drum ML, Hollis BW, Kukreja SC (1998) Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats. Am J Clin Nutr 68(S
Chan KS, Andrade SE, Boles M (2000) Inhibitors of hydroxymethylglutaryl coenzyme A reductase and the risk of fractures among older women. Lancet 355: 2185-2188.
Choi, MJ, Yu TS (2004) Effects of red-yeast-rice supplementation on bone mineral density and bone mineral content in overictomized rats. Kor J Nutr 37(6): 423-430.
Dawns JR, Clearfield M, Weis S (1998) Primary prevention of acute coronary events with Lovastation in men and women with average cholesterol levels. JAMA 74: 667-673.
Edwards CH, Hart DJ, Spector TD (2000) Prastatins and increased bone mineral density in postmenopausal women. Lancet 355: 2218-2219.
Chan KS, Andrade SE, Boles M (2000) Inhibitors of hydroxymethylglutaryl coenzyme A reductase and the risk of fractures among older women. Lancet 355: 2185-2188.
Choi, MJ, Yu TS (2004) Effects of red-yeast-rice supplementation on bone mineral density and bone mineral content in overictomized rats. Kor J Nutr 37(6): 423-430.
Dawns JR, Clearfield M, Weis S (1998) Primary prevention of acute coronary events with Lovastation in men and women with average cholesterol levels. JAMA 74: 667-673.
Edwards CH, Hart DJ, Spector TD (2000) Prastatins and increased bone mineral density in postmenopausal women. Lancet 355: 2218-2219.
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UCI(KEPA) : I410-ECN-0101-2009-594-015329399