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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.9 No.3
- 발행연도
- 2004.9
- 수록면
- 265 - 269 (5page)
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초록· 키워드
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Prunus mandshurica var. glabra Nakai (Rosaceae) is widely distributed in South Korea and bears a fruit with a bitter and astringent taste. An ethyl acetate-soluble extract of Prunus mandshurica was found to exhibit significant cytotoxicity against human leukemia cell lines. Bioassay-directed fractionation of this extract using an MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) cell proliferation assay as a monitor led to the isolation of the bioactive compounds. Two compounds, 1 and 2 were subsequently found to mediate cytotoxicity against U937, human monocytic leukemia cells. The 50% growth inhibitory concentrations (IC_(50)) of compounds 1 and 2 on U937 were 40 and 62 μg/mL, respectively.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSION
ACKNOWLEDGEMENT
REFERENCES
참고문헌 (33)
참고문헌 신청
, 1993 , In Human Medicinal Agents from Plants
, 2003 , Inhibitory activity of flavonoids from Prunus davidiana and other flavonoids on total ROS and hydroxyl radical generation 26 : 809 ~ 815
, 2002 , Further flavonoids from the flowers of Prunus spinosa L 59 : 133 ~ 137
, 2002 , Antioxidative phenolic compounds isolated from almond skins(Prunus amygdalus Batsch). 50 : 2459 ~ 2463
, 2004 , Abscisic acid related compounds and lignans in prunes(Prunus domestica L.) and their oxygen radical absorbance capacity (ORAC). 52 : 344 ~ 349
, 2003 , Inhibitory activity of flavonoids from Prunus davidiana and other flavonoids on total ROS and hydroxyl radical generation 26 : 809 ~ 815
, 2002 , Further flavonoids from the flowers of Prunus spinosa L 59 : 133 ~ 137
, 2002 , Antioxidative phenolic compounds isolated from almond skins(Prunus amygdalus Batsch). 50 : 2459 ~ 2463
, 2004 , Abscisic acid related compounds and lignans in prunes(Prunus domestica L.) and their oxygen radical absorbance capacity (ORAC). 52 : 344 ~ 349
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UCI(KEPA) : I410-ECN-0101-2009-511-018079920