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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.8 No.4
- 발행연도
- 2003.12
- 수록면
- 356 - 364 (9page)
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초록· 키워드
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A methanol extract from seeds of Paeonia lactiflora (Paeoniaceae, peony) was found to possess different antiproliferative activities against four different human cancer cell lines: Hela, MCF-7, HepG2 and HT-29. Furthermore, five different methanol (20, 40, 60, 80 and 100% MeOH) fractions obtained by fractionation of the methanol extract of the seeds on a Diaion HP-20 column exhibited differential antiproliferative effects against the above four cancer cell lines. Among five fractions, the 60% MeOH fraction showed relatively lower antiproliferative activity on MCF-7 estrogen-sensitive breast cancer cell than the other cancer cell lines. Systematic separation of 60% the MeOH fraction by silica gel and Sephadex LH-20 columns led to the isolation of four known stilbenes, trans-resveratrol (1), trans-(+)- ε-viniferin (2), gnetin H (3) and suffruticosol B (4). The four stilbenes (1～4) exerted differential biphasic effects on cell proliferation of MCF-7 cells in a similar manner as genistein, a soybean isoflavone used as a positive reference, in the concentration range from 1.0 to 200 μM. Three stilbenes (1～3) weakly stimulated the proliferation of MCF-7 cells at doses below 10 μM. However, strong antiproliferative effects on MCF-7 cell were exerted by extract 1 at a dose of 200 μM, and by 2 and 3 at doses above 25 μM. In contrast, 4 inhibited the proliferation of MCF- 7 cell at a dose below 25 μM, but stimulated cell proliferation at concentrations of 50 and 100 μM. All four stilbenes (1～4) stimulated the proliferation of ROS 17/2.8 osteoblast-like cells in the range of 10^(-10)～10^(-1) μM. Compound 1 exhibited especially potent proliferative activity, although its activity was weaker than that of genistein. Additionally, three resveratrol oligomers (2～4) also exhibited concentration-dependently moderate proliferative activity, but less than that of 1. These results suggest that resveratrol, and its dimer and trimers from the seeds of Paeonia lactiflora may act as a phytoestrogen, but in a somewhat different manner from that of genistein.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-511-018079364