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자료유형
학술저널
저자정보
Park, Soo-Yeong (Jeju Biodiversity Research Institute, Jeju Technopark) Lim, Hee-Kyoung (Department of Biochemistry, School of Medicine, Jeju National University) Lee, Seog-Jae (Department of Thoracic and Cardiovascular Surgery, Jeju National University) Kimcho, So-Mi (Faculty of Biotechnology, Jeju National University) Park, Sang-Gyu (Division of Life & Environmental Science, Daegu University) Cho, Moon-Jae (Department of Biochemistry, School of Medicine, Jeju National University)
저널정보
한국응용생명화학회 Applied Biological Chemistry Applied Biological Chemistry 제54권 제5호
발행연도
2011.1
수록면
718 - 724 (7page)

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Red variants of S. japonicus show unique ecological characteristics and are indigenous to Jeju Island in South Korea. Various biological activities of red sea cucumber extracts (RSCEs) were evaluated. In comparison with positive controls, anti-oxidant activity of RSCEs was very low. In HL-60 and HT-29 cells, chloroform and ethyl acetate (EtOAc) fractions showed higher than 80 and 60% growth inhibition, respectively. Nuclear condensation and increased pro-apoptotic signaling revealed that RSCEs triggered apoptosis. EtOAc fractions also showed strong anti-inflammatory effects at sub-lethal concentrations in lipolysaccharide-stimulated RAW264.7 cells and suppressed more than 90% of nitric oxide (NO) and prostaglandin 2 productions at 50 ${\mu}g$/mL by inhibiting inducible NO synthase and cydooxygenase-2. Water-soluble fractions showed good antibacterial effects against Staphylococcus aureus and Staphylococcus epidermidis.

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