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- 학술저널
- 저자정보
- 발행연도
- 2005.3
- 수록면
- 87 - 95 (9page)
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Cadmium is well known as a toxic metal and has insulin mimicking effects in rat adipose tissue. This study was undertaken to investigate the effect of CdCl₂on glucose transport and its mechanism in 3T3-L1 adipocytes. CdCl₂exhibits respectively 2.2 and 2.8 fold increases in the 2-deoxyglucose uptake when exposed to 10 and 25 μM of CdCl₂for 12 hr. To investigate the stimulating mechanism of glucose transport induced by CdCl₂, Wortmannin and PD98059 were used respectively as PI3K inhibitor and MAPK inhibitor, which did not affect 2-DOG uptake. This results suggest that induced 2-deoxy-(1-³H)-D-glucose (2-DOG) uptake by CdCl₂ may not be concerned with the insulin signalling pathway. Whereas nifedipine, a calcium channel blocker inhibited the 2-DOG uptake stimulated by CdCl₂. In addition, we also measured the increased production of Reactive oxygen substances (ROS) and glutathione (GSH) level in 3T3-L1 adipocytes to investigate correlation between the glucose uptake and increased production of ROS with H2DCFDA. CdCl₂ increased production of ROS. Induced 2-DOG uptake and increased production of ROS by CdCl₂ were decreased by N-acetylcystein (NAC). And L-buthionine sulfoximine (BSO) a potent inhibitor of γ-GCS, decreased of 2-DOG uptake. Also NAC and BSO changed the cellular GSH level, but GSH/GSSG ratio remained unchanged at 10, 25μM of CdCl₂.
목차
Abstract
서 론
실험방법
실험결과
고 찰
참고문헌
참고문헌 (19)
참고문헌 신청
, emboj1992 , The phosphatidylinositol 3-kinase isactivated by association with IRS-1 during insulinstimulation : 3469 ~ 3479
, 1991 , Enhancement ofglutathione levels in mouse peritoneal macrophages bysodium arsenite,cadmium chloride and glucose, glucoseoxidase 1092 : 175 ~ 9
, 1990 , Molecular biology of mammalianglucose transporters 13 : 198 ~ 208
, 1994 , Phosphatidylinositol 3-kinase activation isrequired for insulin stimulation of pp70 S6 kinase,DNAsynthesis and glucose transporter translocation 14 : 4902 ~ 4911
, 1994 , Inhibition of the translocation of GLUT1 andGLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor,wortmannin 300 : 631 ~ 635
, 1991 , Enhancement ofglutathione levels in mouse peritoneal macrophages bysodium arsenite,cadmium chloride and glucose, glucoseoxidase 1092 : 175 ~ 9
, 1990 , Molecular biology of mammalianglucose transporters 13 : 198 ~ 208
, 1994 , Phosphatidylinositol 3-kinase activation isrequired for insulin stimulation of pp70 S6 kinase,DNAsynthesis and glucose transporter translocation 14 : 4902 ~ 4911
, 1994 , Inhibition of the translocation of GLUT1 andGLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor,wortmannin 300 : 631 ~ 635
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