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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.3
- 수록면
- 75 - 85 (11page)
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This study was aimed to know the effect of cadmium chloride (CdCl₂) on glucose transport in L6 myotube and its action mechanism. CdCl2 increased the 2-deoxy- (1-³H)-D-glucose (2-DOG) uptake 1.9 and 2.4 fold at 10 and 25μM respectively. To investigate the stimulating-mechanism of glucose transport induced by CdCl2, the wortmannin and PD98059 were used as PI3K (phosphatidylinositol 3-kinase) inhibitor and MAPK inhibitor respectively, which did not affect 2-DOG uptake. This fact suggests that CdCl2 induced 2-DOG uptake may not be concerned to the insulin signalling pathway. Whereas nifedipine, a calcium channel blocker, and trifluoperazine, a calmodulin inhibitor, were found to inhibit the 2-DOG uptake stimulted by CdCl₂. In addition, we also measured the ROS (reactive oxygen species) production and GSH level in L6 myotube to investigate the correlation between the glucose uptake and ROS. CdCl₂(25μM) increased ROS generation approximately 1.5 fold and changed the cellular GSH level, but GSSG/GSH ratio remained unchanged. CdCl₂-stimulated 2-DOG uptake and ROS generation were inhibited by N-acetylcystein. And BSO pretreatment, a potent inhibitor of γ-GCS, resulted in the dramatic decrease of 2-DOG uptake and also the increase of the sensitivity to cadmium cytotoxicity. The obtained results suggest that CdCl₂-stimulated glucose uptake might be based on the activation of HMP shunt as an antioxidant defense mechanism of the cells.
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Abstract
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참고문헌 (20)
참고문헌 신청
[학술지(정기간행물)] - / / Insulin and oxytocin effects on phosphoinositidemetabolism in adipocytes Enhancement ofglutathione levels in mouse peritoneal macrophages bysodium arsenite : 3600 175 ~ 3609 9
[학술지(정기간행물)] - / 1991 / Oxygen reactive species and antioxidant responsesduring development:The metabolic paradox of cellulardifferentiation 196 : 117 ~ 129
[학술지(정기간행물)] - / 1990 / Molecular biology of mammalianglucose transporters 13 : 198 ~ 208
[학술지(정기간행물)] - / jclininvest1986 / Studies on themechanism of insulin resistance in the liver from humanswith noninsulin-dipendent diabetes - Insulin action andbinding in isolated hepatocytes : 249 ~ 258
[학술지(정기간행물)] - / 1994 / Phosphatidylinositol 3-kinase activation isrequired for insulin stimulation of pp70 S6 kinase,DNAsynthesis and glucose transporter translocation 14 : 4902 ~ 4911
[학술지(정기간행물)] - / 1991 / Oxygen reactive species and antioxidant responsesduring development:The metabolic paradox of cellulardifferentiation 196 : 117 ~ 129
[학술지(정기간행물)] - / 1990 / Molecular biology of mammalianglucose transporters 13 : 198 ~ 208
[학술지(정기간행물)] - / jclininvest1986 / Studies on themechanism of insulin resistance in the liver from humanswith noninsulin-dipendent diabetes - Insulin action andbinding in isolated hepatocytes : 249 ~ 258
[학술지(정기간행물)] - / 1994 / Phosphatidylinositol 3-kinase activation isrequired for insulin stimulation of pp70 S6 kinase,DNAsynthesis and glucose transporter translocation 14 : 4902 ~ 4911
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