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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1999.6
- 수록면
- 123 - 131 (9page)
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초록· 키워드
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To investigate the influence of melatonin (MLT) on the immunotoxicity of cadmium acetate [Cd(AC)₂] in ICR mice, MLT (10 or 50 mg/kg) was orally administered to mice daily for 28 consecutive days, cadmium (Cd) also administered at 25 mg/kg with the same route 2 hr after administration of MLT, and the normal mice were given vehicle, immunocompetence was evaluated by humoral and non-specific immunity. In Cd plus MLT-treated group, the body weight gains and the relative thymus weights were significantly increased as compared with treatment of Cd alone. The relative spleen and liver weights were increased by treatment of Cd alone, restored to normal value by MLT treatment, Hemagglutination (HA) titer, primary IgM antibody to SRBC and secondary IgG antibody response to BSA was significantly increased in Cd plus MLT-treated mice as compared with treatment of Cd alone. NK cell and phagocytic activity were significantly increased in Cd plus MLT-treated mice as compared with treatment of Cd alone, the number of peripheral leukocytes was significantly increased in Cd plus MLT-treated mice as compared with treatment of Cd alone These results suggest that immunotoxicity induced by Cd was significantly restored or prevented by MLT.
목차
ABSTRACT
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-513-013746564