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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1999.9
- 수록면
- 389 - 393 (5page)
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초록· 키워드
오류제보하기
Primary skin irritation and eye irritation of a new oral combined antibiotic, cefatrizine/clavulantic acid (CFT/CVA, DA-710l), were investigated in albino rabbits. In primary skin irritation study, a single dermal application of CFT/CVA at a dose of 500 mg showed no irritancy on intact skin and very slight erythema and edema on scarified skin (PII=0.46). In eye irritation study, a single intraconjunctival application of 100 mg of CFT/CVA resulted in mild and reversible reactions such as redness and chemosis of conjunctivae, which were disappeared 72 h after the application. The AOI values were 3 and 2.7 for nonirrigation and irrigation, respectively. The present study demonstrates that a single administration of CFT/ CVA to the skin and ocular mucosa is not likely to induce significant local irritation effects.
목차
ABSTRACT
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-513-013746019