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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1999.9
- 수록면
- 263 - 273 (11page)
이용수
초록· 키워드
오류제보하기
It is essential to determine the potential photo-sensitizing properties of chemicals before marketing, as unwanted cutaneous photosensitivity can be induced by any of several hundred chemicals. Until now, the animal studies using guinea pigs, rabbits, rats or mice have been employed for investigating the photo toxic effects of chemicals on the skin. However, it is needed to develop the alternative methods to animal tests, because the animal test costs a great deal, takes long time and requires specialized facilities. In addition, EU proposed the prohibition of animal testing on cosmetics from 2000. In the recent GECD draft proposal for a new guideline on acute dermal photoirritation testing, in vitro screening tests includes in a sequential test strategy. According to the proposal, it should have priority over any animal tests. During the EC/CGLIPA validation study many in vitro photo toxicity test systems, covering several mechanisms of phototoxicity, have been developed. Consequently, it is predicted that in vitro photo toxicity tests will substitute for in vivo tests. At this point, it is necessary for us to review the mechanisms of phototoxicity, standard protocols of in vivo tests, in vitro tests not only for screening purposes but for mechanistic studies, and phototoxicity guideline of GECD, Korea and Japan.
목차
ABSTRACT
Ⅰ. 서론
Ⅱ. 본론
Ⅲ. 결론
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UCI(KEPA) : I410-ECN-0101-2009-513-013745865