지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.6
- 수록면
- 56 - 61 (6page)
이용수
초록· 키워드
오류제보하기
This study was designed to compare the antidiabetic activities between Ginseng Radix Alba (GRA), Ginseng Radix Rubra (GRR) and Panax Quinquefoli Radix (PQR) in multiple low dose (MLD) streptozotocin (STZ) (20 mg/kg i.p injection for 5 days) induced diabetic rats. In the glucose tolerance test, 500 mg/kg of each ginseng ethanol extract was administered intraperitoneally 30 min before glucose challenge. While GRA failed to lower blood glucose level, GRR and PQR both significantly prevented the hyperglycemia when compared with the control group. In the MLD STZ-induced
diabetic rats, 300 mg/kg of each ginseng ethanol extract was administered intraperitoneally for 2 weeks. Plasma glucose
and insulin levels were markedly improved in all treatment groups. While GRR showed the highest antidiabetic activity, and GRA and PQR revealed somewhat equipotent antidiabetic activities, but less than that in GRR-treated group as far as blood parameters and diabetic symptoms such as polyphagia and polydipsia are concerned. Blood glucose levels were closely associated with plasma insulin levels, and this result may suggest that ginseng ethanol extracts showed the activity to enhance insulin secretion as well as preventing destruction of pancreatic islet cells. To elucidate the relationship between antidiabetic activity and ginsenoside profiles, seven major ginsenosides were quantified by HPLC. We figured out the fact that protopanaxatriol (PPT): proptopanaxadiol (PPD) ratio might play an important role in its hypoglycemia
effects.
diabetic rats, 300 mg/kg of each ginseng ethanol extract was administered intraperitoneally for 2 weeks. Plasma glucose
and insulin levels were markedly improved in all treatment groups. While GRR showed the highest antidiabetic activity, and GRA and PQR revealed somewhat equipotent antidiabetic activities, but less than that in GRR-treated group as far as blood parameters and diabetic symptoms such as polyphagia and polydipsia are concerned. Blood glucose levels were closely associated with plasma insulin levels, and this result may suggest that ginseng ethanol extracts showed the activity to enhance insulin secretion as well as preventing destruction of pancreatic islet cells. To elucidate the relationship between antidiabetic activity and ginsenoside profiles, seven major ginsenosides were quantified by HPLC. We figured out the fact that protopanaxatriol (PPT): proptopanaxadiol (PPD) ratio might play an important role in its hypoglycemia
effects.
목차
Abstract
서 론
실험방법
결과 및 고찰
요 약
인용문헌
참고문헌 (1)
참고문헌 신청
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hypoglycemic Effect of Ginseng Radix alba(GRA) in Multiple Low Dose Streptozotocin-induced Diabetic Rats
대한약학회 학술대회
2002 .01
-
Antidiabetic effect and mechanism of Ginseng Radix Rubra, Ginseng Radix Alba, and Ginseng Radix Palva in KKAy mice
대한약학회 학술대회
2001 .01
-
Comparisons of antidiabetic activity between ethanol extract of white ginseng root and IH901 in streptozotocin-induced diabetic rats
대한약학회 학술대회
2002 .01
-
Ginsenosides Content of The Manufactured Ginseng Radices Extracts
대한약학회 학술대회
2002 .01
-
Multiple Low Dose Streptozotocin으로 유도된 당뇨 흰쥐에서 투여 시기에 따른 인삼의 항당뇨 활성 비교
Journal of Ginseng Research
2002 .09
-
Multiple Low Dose Streptozotocin으로 유도된 고혈당 흰쥐에서 인삼ㆍ상엽 단독 및 복합 처방의 항당뇨 효과
약학회지
2002 .01
-
Antidiabetic Effect of Ginseng Radix Alba(GRA) and Mori Folium(MF) on Multiple Low Dose Streptozotocin-induced Diabetic Rats
대한약학회 학술대회
2002 .01
-
Comparisons between White Ginseng Radix and Rootlet for Antidiabetic Activity and Mechanism in KKAy Mice
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2001 .01
-
Comparisons of thermogenic activity among Ginseng Radix Alba (GRA), Ginseng Radix Rubra (GRR), and Panax Quinquefolii Radix (PQR)
대한약학회 학술대회
2002 .01
-
Streptozotocin 유발 당뇨 흰쥐에서 백삼 에탄올엑스와 IH-901의 항당뇨 작용 비교
약학회지
2003 .01
-
전사체 프로파일을 이용한 고려 홍삼의 항당뇨 기전 연구
약학회지
2008 .01
-
Establishment of In Vitro Test System for the Evaluation of the Estrogenic Activities of Natural Products
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
Merit of Ginseng in the Improvement of Insulin Resistance
Journal of Ginseng Research
2010 .09
-
Rapid characterization of ginsenosides in the roots and rhizomes of Panax ginseng by UPLC-DAD-QTOF-MS/MS and simultaneous determination of 19 ginsenosides by HPLC-ESI-MS
Journal of Ginseng Research
2016 .10
-
홍삼과 백삼의 비교 고찰
Journal of Ginseng Research
2005 .03
-
Wild Ginseng Prevents the Onset of High-Fat Diet Induced Hyperglycemia and Obesity in ICR Mice
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
팽화홍삼 분말 및 음료 식이가 Streptozotocin 유발 당뇨쥐의 혈당 및 혈청지질에 미치는 영향
심건섭
,
성기승
,
이경원
외 4명
한국식품영양과학회지
2015
.10
발효홍삼이 제2형 당뇨병 환자의 혈당 및 인슐린저항성에 미치는 영향
김혜옥
,
박민정
,
한지숙
한국식품영양과학회지
2011
.05
김치로부터 분리한 Leuconostoc citreum GJ7의 마우스에 대한 급성독성
이재준
,
장해춘
,
이명렬
한국식품영양과학회지
2007
.05
C57BL/6 Mice에서 이소플라본의 지질강하, 항산화, 항염증효과를 통한 항동맥경화 효과
조혜연
,
양정례
,
노경희
외 4명
한국식품영양과학회지
2007
.03
김치종류별 식이가 Hairless Mouse 피부의 형태학적 변화에 미치는 영향
류복미
,
류승희
,
양영철
외 3명
한국식품영양과학회지
2004
.11
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-524-013720247