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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.12
- 수록면
- 311 - 324 (14page)
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Toxicokinetic studies are intended to provide critical evaluation of drug disposition at toxicological doses and help understand the relationship between blood or tissue levels and the time course of toxic events. Relatively high dose levels used in toxicokinetics, compared to pharmacokinetics, complicates absorption, protein binding, metabolism and elimination processes. In this mini review, frequently used toxicokinetic models such as linear compartment medels, physiological models, and nonlinear kinetic models are introduced. In addition, optimization of toxicokinetic studies, their role in the drug development process, and prediction of human toxicokinetics based on animal data by interspecies scaling are briefly discussed.
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UCI(KEPA) : I410-ECN-0101-2009-513-013456550