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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.9
- 수록면
- 285 - 292 (8page)
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초록· 키워드
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The repeated toxicity of Gleditschia-saponin produced and provided by S.S. Bio-Rech Bench Co. was wvaluated in Sprague-Dawley rats. Gleditschia-saponin was administered to rats by oral route at dose levels of high (180 mg/kg/day), medium (90 mg/kg/day) and low (45 mg/kg/day) once a day for 14 days. Saline was administered to another group of rats as contraol. Each group was consisted of 5 male and female rats. There were no dose-related changes in clinical findings, food and water consumptions, organ weights, urine analysis, biochemical examination and hematological findings in all groups of animals treated with Gleditschia.- saponin, except body weights. Body weights in male and female rats were increased significantly ([<0.05) from day 4 to 14 in low, middle and high dose groups than control group. Bhdy weight in high dose group was increased higher than control or low, middle dose groups in day 14. Gross and histopathological findings revealed no evidence of specific toxicity to Gleditschia-saponin. Therefore, it was concluded that Gleditschia-saponin had no toxic or side effects in Sprague-Dawley rats in an repeated oral toxicity tests.
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UCI(KEPA) : I410-ECN-0101-2009-513-013456525