지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 송기창
- 발행연도
- 2020
- 저작권
- 건양대학교 논문은 저작권에 의해 보호받습니다.
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초록· 키워드
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The use of stents is important for the treatment and preservation of benign and malignant bile duct obstructions. Plastic and metal stents for biliary tract are affected by food and biofilm. This results in problems such as restenosis and closure of the stent by cells growth. This requires that the stent be removed or reinserted every 3 ~ 6 months. As a solution, the study and application of biodegradable stents in the treatment of biliary Disease has attracted attention. Biodegradable polymer(BP) is advantageous for drug release and easily controls the biodegradation period. However, the mechanical strength is weak compared to Biodegradable metal(BM). BM has excellent mechanical strength and radiopacity but is difficult to control corrosion time.
In the present work, a drug-containing polymer coating was applied on the magnesium alloy wire surface. This aimed to control the sustained release of the drug and the biodegradation time of the stent. Based on the mechanical properties of the magnesium alloy wire, the applicability of the biliary stent was confirmed. The degradation behavior was observed for 30 days through in-vitro experiments. The analysis was performed using SEM analysis, pH measurement, weight loss measurement, and HPLC analysis.
As a result of analysis, the corrosion period of magnesium alloy wire, which was broken in 3 ~ 5 days, was extended to 20 ~ 30 days depending on the type of polymer coating. We can see the clear difference between bulk erosion and surface erosion polymers. The present study shows that surface-decomposed PPC is more suitable for controlling the biodegradation behavior and sustained release of the drug compared to bulk decomposed polymers such as PCL, PLGA, and PLLA.
In the present work, a drug-containing polymer coating was applied on the magnesium alloy wire surface. This aimed to control the sustained release of the drug and the biodegradation time of the stent. Based on the mechanical properties of the magnesium alloy wire, the applicability of the biliary stent was confirmed. The degradation behavior was observed for 30 days through in-vitro experiments. The analysis was performed using SEM analysis, pH measurement, weight loss measurement, and HPLC analysis.
As a result of analysis, the corrosion period of magnesium alloy wire, which was broken in 3 ~ 5 days, was extended to 20 ~ 30 days depending on the type of polymer coating. We can see the clear difference between bulk erosion and surface erosion polymers. The present study shows that surface-decomposed PPC is more suitable for controlling the biodegradation behavior and sustained release of the drug compared to bulk decomposed polymers such as PCL, PLGA, and PLLA.
목차
제1장 서론 1제1절 연구의 목적 1제2장 이론 4제1절 스텐트 41-1. 스텐트 개요 41-2. 스텐트 구분 51-3. 스텐트 변천사 6제2절 마그네슘 및 마그네슘 합금 82-1. 마그네슘 82-2. 체내 마그네슘의 항상성 92-3. 마그네슘의 부식거동 92-4. 마그네슘 및 마그네슘 합금의 적용 102-5. 마그네슘의 성능 향상 11제3절 담관 폐색 및 치료 133-1. 담관 133-2. 담관 폐색 및 치료 133-3. 생분해성 담관용 스텐트 14제3장 실험 및 방법 16제1절 실험 재료 16제2절 실험 및 분석 방법 182-1. 스텐트 형상 직조 182-2. 고분자 코팅 도막 제조 202-3. 약물이 포함된 코팅 도막 제조 202-4. 기계적 물성 측정 222-5. 코팅된 마그네슘 합금 와이어의 표면 및 단면 분석 232-6. 유기용매가 약물에 끼치는 영향 분석 232-6. 용액의 pH 분석 232-7. 무게 변화 분석 242-8. HPLC 분석 24제4장 결과 및 고찰 25제1절 직조 구조 및 코팅 도막이 기계적 물성에 미치는 영향 25제2절 고분자 코팅 도막이 형성된 마그네슘 와이어의 분해 거동 32제3절 약물 방출 거동 44제5장 결론 49참고문헌 50영문초록(국문요약) 59감사의 말씀(필요시) 61
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