목차

Chapter 1. General Introduction
1.1. Tissue adhesive biomaterials 1
1.1.1. Synthetic polymer 1
1.1.2. Natural polymers 3
1.1.3. Nature-inspired materials 6
1.2. Oxygen in wound healing process 10
1.2.1. Wound healing process 10
1.2.2. The role of hyperoxia in wound healing process 13
1.2.3. Current strategies for oxygen therapies 15
1.2.3.1. Oxygen-delivery system 15
1.2.3.2. Oxygen-generating system 15
1.3. Research Motivation and Approaches 18
Chapter 2. Oxygen-generating Tissue Adhesive Hydrogels
2.1. Introduction 20
2.2. Objectives 24
2.3. Experimental Section 25
2.3.1. Materials 25
2.3.2. Synthesis and preparation of the GtnSH-PD hydrogels 26
2.3.3. Phase transition time and rheological analysis 26
2.3.4. Quantification of released H2O2 concentrations 28
2.3.5. Oxidation kinetics of dopamine 28
2.3.6. Dopamine-releasing kinetics from the hydrogel matrixes 28
2.3.7. Measurement of dissolved oxygen (DO) level 29
2.3.8. Cytocompatibility of the GtnSH-PD hydrogels 29
2.3.9. Measurement of tissue adhesive strength 30
2.3.10. In vivo degradation of GtnSH-PD hydrogels 30
2.3.11. In vivo biocompatibility and angiogenic effect of the hydrogels 31
2.3.12. In vivo wound healing study 31
2.3.13. In vivo hemostatic ability test 32
2.3.14. Histological analysis 32
2.3.15. Statistical Analysis 32
2.4. Results and Discussion 33
2.4.1. Tunable physicochemical properties of the hydrogels 33
2.4.2. Generation and decomposition of H2O2 from the hydrogels 36
2.4.3. CaO2-mediated in situ polymerization of dopamine 40
2.4.4. Controllable oxygen tension of the hydrogels 43
2.4.5. Improved tissue adhesive properties of the hydrogels 45
2.4.6. Cytocompatible oxygen-generating bioadhesive 47
2.4.7. In vivo degradability of the hydrogels 50
2.4.8. In vivo angiogenic effect and enhanced wound healing ability 52
2.4.9. In vivo hemostatic capacity of the hydrogels 54
Chapter 3. Conclusion and Future Direction