As the world country enters an aging society along with economic growth, dementia is becoming a social problem beyond the members of family. The TMS(Transcranial Magnetic Stimulation) is known to affect electrical signals and structural changes in the brain through high-power magnetic fields. In particular, a number of prior studies are being conducted for clinical therapeutic purposes for depression and antipsychotic diseases, and the recent release of research results on cognitive and memory enhancement through repetitive transcranial magnetic electrodes has emerged as a treatment method for the cognitive and memory degradation problems of dementia.
In this paper, it was to design and manufacture of rTMS(repetitive Transcranial Magnetic Stimulation) in order to conduct experiments on the improvement of cognition and memory due to rTMS for STZ(Steptozotocin) dementia-induced animal model using the prepared rTMS. Rat model is 3 type - 1. control group (normal) without surgical procedure, 2. comparative control group (dementia Induction) of STZ(Steptozotocin) dementia-induced, 3. experimental group (Dementia induction + rTMS) that underwent surgical procedure using STZ. We studied the structural change, cognition, and memory of Rat brain using rTMS.
In the Y-maze experiment which can confirm the cognition and memory, control group and comparative control group showed a decrease in memory (about 21%) to 79% of control group. In contrast, Experimental group was 94%, which not only improved cognition and memory, but also showed a similar or slightly lower level than control group.
As the experiment proceeded, hepatotoxicity test was performed to determine whether rTMS adversely affects physical changes due to other environmental factors or coil magnetic fields. As a result, hepatotoxicity functions such as Albumin, AST, and ALT were in the normal category, and it was confirmed that rTMS had no effect on hepatotoxicity of all Rat models.


After completion of all experiments, the hippocampus was stained with Nissl stain to confirm the brain structure change through rTMS. CA1, CA2, CA3, DG regions of the hippocampus which are important for cognition and memory were observed by optical microscope. No qualitative result was observed in control group and comparative control group. And no qualitative result was observed in the comparison between control group and experimental group. However, qualitative result came near between control group and experimental group.
In this paper, it could be suggested that rTMS had a positive effect on the dementia induction model, which could be suggested as a method for treating dementia, a degenerative brain disease.