지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 김재철
- 발행연도
- 2018
- 저작권
- 전북대학교 논문은 저작권에 의해 보호받습니다.
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초록· 키워드
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In order to analyze how the protein synthesis and degradation gene expression changes by muscle fiber type depending on the degree of atrophy after sciatic nerve injury, this study was conducted to analyze the difference of myoatrophy-related genes according to the recovery period after damaging the left sciatic nerve of the white rats. For this purpose, 16 Spargue-Dawley male rats were randomly divided in sham, 5days, and 10day groups and the expression of MyoD, Myogenin, MuRF1 and MAFbx was analyzed in gastrocnemius, extensor digitorum longus, soleus.
The Sciatic nerve injury group decreased in weight as time elapsed, but sham group decreased and recovered. Dietary intake decreased in both groups and then increased again and given that there is no difference in dietary intake among groups, dietary intake is thought to have no effect on body weight and skeletal muscle weight.
The skeletal muscle weights were significantly different between the three groups due to the difference in injury duration in all three muscles, Type I soleus is considered to be significantly contracted than Type II extensor digitorum longus muscle due to Sciatic nerve injury
The expression of MyoD, Myogenin, MuRF1, and MAFbx in gastrocnemius, extensor digitorum longus muscle, soleus contracted with scatic nerve injury was increased compared to the sham group. In addition, the expression of MyoD was found to be higher in extensor digitorum longus muscle composed of Type II fibers, and that of Myogenin was higher in soleus composed of Type I fibers. The expression of MuRF1 was mainly high in extensor digitorum longus muscle, and that of MAFbx was mainly high in gastrocnemius and soleus.
The Sciatic nerve injury group decreased in weight as time elapsed, but sham group decreased and recovered. Dietary intake decreased in both groups and then increased again and given that there is no difference in dietary intake among groups, dietary intake is thought to have no effect on body weight and skeletal muscle weight.
The skeletal muscle weights were significantly different between the three groups due to the difference in injury duration in all three muscles, Type I soleus is considered to be significantly contracted than Type II extensor digitorum longus muscle due to Sciatic nerve injury
The expression of MyoD, Myogenin, MuRF1, and MAFbx in gastrocnemius, extensor digitorum longus muscle, soleus contracted with scatic nerve injury was increased compared to the sham group. In addition, the expression of MyoD was found to be higher in extensor digitorum longus muscle composed of Type II fibers, and that of Myogenin was higher in soleus composed of Type I fibers. The expression of MuRF1 was mainly high in extensor digitorum longus muscle, and that of MAFbx was mainly high in gastrocnemius and soleus.
목차
Ⅰ. 서 론 11. 연구의 필요성 12. 연구의 목적 33. 연구의 가설 34. 연구의 제한점 4Ⅱ. 연 구 방 법 51. 실험동물 52. 실험방법 53. 분석방법 64. 자료처리방법 8Ⅲ. 연 구 결 과 91. 체중 92. 식이섭취량 103. 골격근 무게 114. 비복근 내 근 단백질 합성 및 분해인자의 발현 125. 장지신근 내 근 단백질 합성 및 분해인자의 발현 146. 가자미근 내 근 단백질 합성 및 분해인자의 발현 16Ⅳ. 논 의 18Ⅴ. 결 론 23Ⅵ. 참 고 문 헌 24
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